Localization of the CAMKG gene encoding γ isoforms of multifunctional calcium/calmodulin-dependent protein kinase (CaM kinase) to human chromosome 10 band q22 and mouse chromosome 14Li X.a · Nghiem P.b,c · Schulman H.b · Francke U.a,d
aHoward Hughes Medical Institute, dDepartments of Genetics and Pediatrics, and Departments of bPharmacology and cMedicine, Stanford University Medical Center, Stanford CA (USA)
Multifunctional calcium/calmodulin-dependent protein kinase (CaM kinase) is an enzyme mediating calcium-dependent signal transduction pathways. CaM kinase exists in a variety of isoforms, each with a distinct tissue-specific expression pattern, that enables the kinase to regulate multiple functions in mammalian systems. Here we report the chromosomal localization of the previously cloned human γ-CaM kinase gene (CAMKG). By using a mapping panel of human × Chinese hamster somatic cell hybrid lines and fluorescence in situ hybridization, we have assigned human CAMKG to chromosome 10q22. We have partially cloned the murine γ-CaM kinase gene and mapped it Camkg to mouse chromosome 14 by analyzing a panel of mouse × rodent somatic cell hybrid lines. A recessive gene, asa, implicated in the control of autoimmune response, is located within the predicted region for Camkg.
© 1994 S. Karger AG, Basel
Request reprints from Dr. Uta Francke, Howard Hughes Medical Institute, Stanford University Medical Center, Stanford CA 94305-5428; telephone: 415-725-8089; fax:415-725-8112.
Received: 18 October 1993
Published online: May 15, 2008
Number of Print Pages : 4
Cytogenetic and Genome Research
Vol. 66, No. 2, Year 1994 (Cover Date: 1994)
Journal Editor: Schmid M. (Würzburg)
ISSN: 1424–8581 (Print), eISSN: 1424–859X (Online)
For additional information: http://www.karger.com/CGR