Gene Mapping, Cloning, and Sequencing
Human gp130 transducer chain gene (IL6ST) is localized to chromosome band 5q11 and possesses a pseudogene on chromosome band 17p11Rodriguez C.a · Grosgeorge J.b · Nguyen V.C.c · Gaudray P.b · Theillet C.a
aInstitut de Génétique Moléculaire de Montpellier, CNRS UMR 9942, Montpellier; baboratoire de Génétique Moléculaire des Cancers Humains, CNRS URA 1462, UFR de Médecine, Nice; and caboratoire de Cytogénétique et Génétique Oncologiques, CNRS URA 1158, Institut Gustave Roussy, Villejuif (France)
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Human gp130 (IL6ST) is one of the most widely used chains of the cytokine receptor family. Indeed, it is involved in signal transduction of interleukin-6, interleukin-11 leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor. In a previous report, IL6ST was assigned to chromosomes 5 and 17. Here we specify the chromosomal sub-localization of IL6ST and show that the sequence detected on 17p11 corresponds, in fact, to a nontranscribed pseudogene, whereas the active gene is located at chromosome band 5q11.
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