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Vol. 73, No. 1-2, 1996
Issue release date: 1996
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Cytogenet Cell Genet 1996;73:130–133
(DOI:10.1159/000134323)
Gene Mapping, Cloning, and Sequencing

Isolation and mapping of a human gene (RPD3L1) that is homologous to RPD3, a transcription factor in Saccharomyces cerevisiae

Furukawa Y.a,b · Kawakami T.a · Sudo K.a · Inazawa J.c · Matsumine A.d · Akiyama T.d · Nakamura Y.a
aLaboratory of Molecular Medicine, The Institute of Medical Science, The University of Tokyo; bFirst Department of Surgery, The University of Tokyo, Tokyo; cDepartment of Hygiene, Kyoto Prefectural University of Medicine, Kyoto; dDepartment of Oncogene Research, Research Institute for Microbial Diseases, Osaka University, Osaka (Japan) Cytogenet Cell Genet 1996;73:130–133 (DOI:10.1159/000134323)

Abstract

We have isolated a novel human gene RPD3L1, that is highly homologous to a transcription factor in Saccharomyces cerevisiae, RPD3 (reduced potassium dependency 3), from a human fetal lung cDNA library. The cDNA clone, hRPD3, consists of 2,100 nucleotides that contain an open reading frame of 1446 nucleotides encoding 482 amino acids. It shares 62% identity in nucleotide sequence and 52% identity in amino acid sequence to RPD3. This gene is expressed at various levels in all tissues examined. Furthermore, we were able to map it to chromosome band 1p34.1 by FISH.

 goto top of outline Author Contacts

Request reprints from Yusuke Nakamura, M.D., Ph.D., Laboratory of Molecular Medicine, The Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108 (Japan); telephone: 81-3-5449-5372; fax: 81-3-5449-5433; e-mail: yusuke@ims.u-tokyo.ac.jp


 goto top of outline Article Information

Received: 5 July 1995
Published online: May 20, 2008
Number of Print Pages : 4


 goto top of outline Publication Details

Cytogenetic and Genome Research

Vol. 73, No. 1-2, Year 1996 (Cover Date: 1996)

Journal Editor: Schmid M. (Würzburg)
ISSN: 1424–8581 (Print), eISSN: 1424–859X (Online)

For additional information: http://www.karger.com/CGR


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