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Table of Contents
Vol. 77, No. 3-4, 1997
Issue release date: 1997
Section title: Gene Mapping, Cloning, and Sequencing
Cytogenet Cell Genet 1997;77:253–256
(DOI:10.1159/000134588)

Comparative genomic hybridization analysis of Y79 and FISH mapping indicate the amplified human mitochondrial ATP synthase α-subunit gene (ATP5A) maps to chromosome 18q12→q21

Godbout R.a · Pandita A.b · Beatty B.b · Bie W.a · Squire J.A.b
aDepartment of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta; bDepartments of Medical Biophysics and Pathology, University of Toronto and Department of Pathology, Princess MargaretHospital and Ontario Cancer Institute, Toronto, Ontario (Canada)

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Article / Publication Details

First-Page Preview
Abstract of Gene Mapping, Cloning, and Sequencing

Accepted: February 27, 1997
Published online: May 20, 2008
Issue release date: 1997

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR

Abstract

The four mitochondrial ATP synthase α-subunit (ATP5A) genes map to chromosomes 2, 9, 16, and 18. In this study we have refined the localization of two of these genes by fluorescence in situ hybridization (FISH) to metaphase spreads, and further characterised the involvement of ATP5A in the amplification process in the retinoblastoma cell line Y79. Comparative genomic hybridization (CGH) analysis of Y79 indicated that gene amplification was present on both the short arm of chromosome 2 and the long arm of chromosome 18. FISH indicated that the functional ATP5A gene mapped to 18q12→q21 the same band location identified by CGH analysis of Y79. An ATP5A pseudogene (ATP5AP1) maps to 9p12. Gains in chromosomal material at 18q12→q21 likely involve hybridization to amplified copies of the ATP5A gene while gains at 2p24 represent hybridization to the MYCN and DDX1 genes, also amplified in Y79.

© 1997 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Gene Mapping, Cloning, and Sequencing

Accepted: February 27, 1997
Published online: May 20, 2008
Issue release date: 1997

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


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