Gene Mapping, Cloning, and Sequencing
Molecular cloning and mapping of a human cDNA (PA2G4) that encodes a protein highly homologous to the mouse cell cycle protein P38-2G4Lamartine J.a · Seri M.b · Cinti R.b · Heitzmann F.a · Creaven M.a,b · Radomski N.c · Jost E.c · Lenoir G.M.a · Romeo G.a,b · Sylla B.S.a
aInternational Agency for Research on Cancer, Lyon (France); bLaboratorio di Genetica Molecolare, Istituto G. Gaslini, Largo G. Genova Quarto (Italy); cJustus Liebig-Universität, Giessen (Germany)
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We have identified a novel human gene with strong homology to the mouse Pa2g4 cell cycle gene. This novel gene (called PA2G4) belongs to a gene family with members in several chromosome regions: 3q24-q25, 6q22, 9q21, 12q13, 18q12, 20p12 and Xq25. A composite cDNA of 1697 nucleotides was isolated. The sequence of this cDNA predicts a protein of 394 amino acids. The deduced amino acid sequence of this human protein shows very strong homology to the mouse protein p38–2G4. The cDNA analyzed probably corresponds to a functional copy found at 12q13.
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