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Table of Contents
Vol. 78, No. 3-4, 1997
Issue release date: 1997
Section title: Gene Mapping, Cloning, and Sequencing
Cytogenet Cell Genet 1997;78:295–300
(DOI:10.1159/000134676)

Molecular cloning of a novel gene similar to myeloid antigen CD33 and its specific expression in placenta

Takei Y.ab · Sasaki S.a · Fujiwara T.c · Takahashi E.c · Muto T.b · Nakamura Y.a
aLaboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, Tokyo; bDepartment of Surgery I, Tokyo University Medical School, Tokyo; cOtsuka GEN Institute, Otsuka Pharmaceutical Co Ltd., Tokushima (Japan)

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Article / Publication Details

First-Page Preview
Abstract of Gene Mapping, Cloning, and Sequencing

Accepted: March 03, 1997
Published online: May 20, 2008
Issue release date: 1997

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR

Abstract

We have isolated a novel gene that encodes a protein sharing significant similarity with myeloid antigen CD33. The complete cDNA contains an open reading frame of 1,326 nucleotides encoding 442 amino acids. The deduced amino acid sequence indicates that this molecule belongs to the immunoglobulin (1g) superfamily and is likely to be a new member of the sialoadhesin sub-family. It is composed of three 1g-like domains; its high degree of similarity to CD33 (70% identity) in the first and second of these domains implies that the placenta-specific gene product is likely to be associated with cell-cell interaction. Northern-blot analysis revealed transcripts of four distinct sizes, 7.5 kb, 5.0 kb, 4.1 kb, and 2.0 kb, specifically in the placenta. Consequently, we termed this gene CD33L (CD33 antigen-like). An alternatively-spliced transcript encoding a 342-amino-acid peptide which lacked the transmembrane region and the cytoplasmic tail was also isolated. We mapped CD33L by fluorescence in situ hybridization (FISH) to human chromosome 19q13.3, where the CD33 gene is also located.

© 1997 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Gene Mapping, Cloning, and Sequencing

Accepted: March 03, 1997
Published online: May 20, 2008
Issue release date: 1997

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


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