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Table of Contents
Vol. 79, No. 1-2, 1997
Issue release date: 1997
Section title: Gene Mapping, Cloning, and Sequencing
Cytogenet Cell Genet 1997;79:125–131
(DOI:10.1159/000134699)

Detailed map of a region commonly amplified at 11q13→q14 in human breast carcinoma

Bekri S.a · Adélaïde J.b · Merscher S.a,c · Grosgeorge J.a · Caroli-Bosc F.a · Perucca-Lostanlen D.a · Kelley P.M.d · Pébusque M.-J.e · Theillet C.f · Birnbaum D.b,e · Gaudray P.a
aInstabilité et Altérations des Génomes, UNSA/CNRS UMR 6549, Nice; bLaboratoire de biologie des tumeurs, Institut Paoli-Calmettes, Marseille (France); cInstitut für Humangenetik, Universität des Saarlandes, Homburg (Germany); dBoys Town National Research Hospital, Omaha NE (USA); eINSERM Ul 19, Marseille; fCentre de Recherche – CRLC Val d’Aurelle-Paul Lamarque, Montpellier (France)

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Article / Publication Details

First-Page Preview
Abstract of Gene Mapping, Cloning, and Sequencing

Accepted: September 19, 1997
Published online: May 20, 2008
Issue release date: 1997

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR

Abstract

Amplification of loci present on band q13 of human chromosome 11 is a feature of a subset of estrogen receptor positive breast carcinomas prone to metastasis. As many as five distinct amplification units have been described on 11q13. They include particularly a genomic area encompassing the GARP gene at 11q13.5→q14.1. We have reassessed our current knowledge of this region, located telomeric to CCND1 and EMS1, which is amplified in 7–10% of mammary tumors. The loose definition of the driving forces of these amplification events led us to map accurately the boundaries of the amplifiable region, and thus to contribute a physical and transcriptional map of a 3-Mb region of chromosome 11. Four new genes were placed on the regional map, namely CBP2, CLNSIA, UVRAG, and PAKl. We have narrowed the core of the 11q13→q14 amplicon to a 350-kb area encompassing D11S533, mostly on its telomeric side. The map reported here represents an indispensable step toward sequencing the entire region, and thus toward uncovering gene(s) which play(s) a critical role in breast cancer progression.

© 1997 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Gene Mapping, Cloning, and Sequencing

Accepted: September 19, 1997
Published online: May 20, 2008
Issue release date: 1997

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


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