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Vol. 147, No. 2, 2008
Issue release date: September 2008
Section title: Original Paper
Int Arch Allergy Immunol 2008;147:140–146
(DOI:10.1159/000135701)

IgE-Independent Mast Cell Activation Augments Contractility of Nonpregnant and Pregnant Guinea Pig Myometrium

Bytautiene E. · Vedernikov Y.P. · Saade G.R. · Romero R. · Garfield R.E.
aDepartment of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Tex., and bPerinatology Research Branch, National Institute of Child Health and Human Development/National Institutes of Health/Department of Health and Human Services, Bethesda, Md., and Detroit, Mich., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 6/27/2007
Accepted: 1/14/2008
Published online: 6/3/2008

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 1

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Background: We have previously shown that in sensitized guinea pigs premature labor can be induced by a type I hypersensitivity reaction. We further hypothesize that premature labor occurs due to increased uterine contractility caused by activation of mast cells and possibly eosinophils, and collective release of their mediators. The objective of this study was to test the hypothesis that IgE-independent mast cell degranulation could increase uterine contractility. Methods: Longitudinal uterine strips from nonpregnant and pregnant guinea pigs were incubated in organ chambers with vehicle, histamine H1, serotonin 5-HT2/5-HT1C, thromboxane A2, leukotriene D4 receptor antagonists, mast cell stabilizer, and cyclooxygenase or lipoxygenase inhibitors. Then, supernatant, obtained after activation of a mast cell line (MC/9) with compound 48/80, culture medium, or compound 48/80 alone were added. Cumulative concentration-response curves to histamine and serotonin were also obtained. Results: The supernatant and compound 48/80 significantly increased contractility of uterine strips. A mast cell stabilizer considerably reduced the effect of compound 48/80. Other substances attenuated uterine contractile responses to supernatant and compound 48/80, and responses varied depending on the pregnancy period. Histamine and serotonin increased contractility of uterine strips, and uterine sensitivity to these agents were dependent on gestational age. Conclusions: In summary, mast cells increase uterine contractility through multiple mediators, and uterine responses to these mediators are dependent on gestational age. We postulate that the simultaneous release of these mast cell/eosinophil mediators in the uterus could be a stimulus to trigger and/or maintain myometrial contractions during preterm and term labor.


  

Author Contacts

Correspondence to: Dr. Egle Bytautiene
Department of Obstetrics and Gynecology, University of Texas Medical Branch
301 University Blvd., Rt. J-62
Galveston, TX 77555-1062 (USA)
Tel. +1 409 747 5139, Fax +1 409 772 2261, E-Mail egbytaut@utmb.edu

  

Article Information

Received: June 27, 2007
Accepted after revision: January 14, 2008
Published online: June 3, 2008
Number of Print Pages : 7
Number of Figures : 4, Number of Tables : 1, Number of References : 23

  

Publication Details

International Archives of Allergy and Immunology

Vol. 147, No. 2, Year 2008 (Cover Date: September 2008)

Journal Editor: Valenta R. (Vienna)
ISSN: 1018–2438 (Print), eISSN: 1423–0097 (Online)

For additional information: http://www.karger.com/IAA


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 6/27/2007
Accepted: 1/14/2008
Published online: 6/3/2008

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 1

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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