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Table of Contents
Vol. 20, No. 4, 2000
Issue release date: July – August
Section title: Case Report
Am J Nephrol 2000;20:332–338
(DOI:10.1159/000013610)

Lactic Acidosis in the Setting of Antiretroviral Therapy for the Acquired Immunodeficiency Syndrome

A Case Report and Review of the Literature

Shaer A.J. · Rastegar A.
Division of Nephrology, Yale University School of Medicine, New Haven, Conn., USA

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Article / Publication Details

First-Page Preview
Abstract of Case Report

Published online: September 01, 2000
Issue release date: July – August

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 1

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN

Abstract

Type B lactic acidosis, a rare but often fatal disorder, has been reported in 21 AIDS patients on antiretroviral therapy (ART). We present an AIDS patient with severe and prolonged lactic acidosis on stavudine and lamivudine. The lactic acidosis occurred in the absence of mitochondrial myopathy, hepatomegaly, or liver failure. This is the second report of lactic acidosis in a patient on stavudine and lamivudine. This patient recovered after aggressive supportive therapy including intravenous alkali and fluid administration as well as continuous venovenous hemodiafiltration. A single dose of dichloroacetate (DCA) was associated with a decrease in the serum lactate level by 20%, which persisted for more than 24 h. Seventeen months after recovery, the patient was rechallenged with ART without recurrence of lactic acidosis. We review and summarize all reported cases of patients with ART-associated lactic acidosis reported in the English literature.

© 2000 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Case Report

Published online: September 01, 2000
Issue release date: July – August

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 1

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN


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