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Vol. 9, No. 5, 1973
Issue release date: 1973
Section title: Paper
Pharmacology 1973;9:312–316
(DOI:10.1159/000136402)

Evidence for the Biogenic Formation of Amphetamine Derivatives from Components of Nutmeg

Braun U. · Kalbhen DA.
Institute of Pharmacology (Director: Prof. Dr. R. Domenjoz), University of Bonn, Bonn

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: 12/20/1972
Published online: 5/28/2008
Issue release date: 1973

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: http://www.karger.com/PHA

Abstract

Myristicin and elemicin are phenylallyl derivatives present in nutmeg. The similarity of their chemical structure to that of mescaline or certain amphetamine derivatives has led to the assumption that the psychotropic effect of nutmeg in man is due to amphetamine derivatives endogenously produced from these phenylallyl precursors by bio-transformation. In our present study we investigated the metabolism of myristicin by rat liver, using the isolated perfused liver or incubation of liver homogenate. We have experimentally proved for the first time that rat liver is capable of converting myristicin into 3-methoxy-4,5-methylenedioxyamphetamine (MMDA). Identification of MMDA was achieved by two-dimensional thin-layer chromatography of the dansylated amine and further by mass spectroscopy.

© 1973 S. Karger AG, Basel


  

Author Contacts

Request reprints from: Prof. Dr. A. Kalbhen, Institute of Pharmacology, University of Bonn, Reuterstr. 2, D-53 Bonn (FRG)

  

Article Information

Received: December 20, 1972
Published online: May 28, 2008
Number of Print Pages : 5

  

Publication Details

Pharmacology (International Journal of Experimental and Clinical Pharmacology)

Vol. 9, No. 5, Year 1973 (Cover Date: 1973)

Journal Editor: Donnerer J. (Graz), Billingsley M.L. (Hershey, Pa.), Maeyama K. (Matsuyama)
ISSN: 0031–7012 (Print), eISSN: 1423–0313 (Online)

For additional information: http://www.karger.com/PHA


Article / Publication Details

First-Page Preview
Abstract of Paper

Received: 12/20/1972
Published online: 5/28/2008
Issue release date: 1973

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: http://www.karger.com/PHA


Copyright / Drug Dosage

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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