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Table of Contents
Vol. 73, No. 5-6, 2007
Issue release date: June 2008
Section title: Clinical Study
Oncology 2007;73:401–406
(DOI:10.1159/000136795)

Outcome of Patients with Melanoma and Histologically Negative Sentinel Lymph Nodes: One Institution’s Experience

De Giorgi V.a · Leporatti G.b · Massi D.c · Lo Russo G.b · Sestini S.a · Dini M.b · Lotti T.a
Departments of aDermatology, bPlastic Surgery and cHuman Pathology and Oncology, University of Florence, Florence, Italy

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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: November 28, 2007
Accepted: November 29, 2007
Published online: June 02, 2008
Issue release date: June 2008

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 2

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL

Abstract

Background: Since its introduction by Morton in 1992, sentinel lymph node (SLN) biopsy has become a standard procedure in the staging and treatment of primary melanoma and clinically negative regional lymph nodes. The primary aims of this procedure are to ascertain the individual lymphatic drainage patterns of primary tumors towards 1 or more different lymph node basins and to identify patients with micrometastatic lymphatic disease for selective lymphadenectomy. The aim of our study was to evaluate over time a cohort of patients who, having undergone SLN treatment, were found negative for metastases using routine histopathological and immunohistochemical analyses. Methods: We studied 102 consecutive patients who underwent intraoperative lymphatic mapping at the Department of Plastic Surgery, University of Florence, Italy, for cutaneous melanoma and were found negative for metastatic melanoma in their SLNs using routine histopathological and immunohistochemical techniques. Results: Of 102 patients with 103 cutaneous melanomas that underwent SLN resection and proved histologically negative to metastasis in that site, 15 patients (14.7%) developed melanoma recurrence during follow-up. Conclusions: The diagnostic and prognostic value of the absence of melanoma metastases in SLNs may be limited and not particularly significant, since satellite and in-transit metastases or direct distant metastases will not be detected and hematogenous spread may already have begun at the time of intervention.

© 2008 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: November 28, 2007
Accepted: November 29, 2007
Published online: June 02, 2008
Issue release date: June 2008

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 2

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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