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Table of Contents
Vol. 28, No. 5, 2008
Issue release date: September 2008
Section title: Original Report: Laboratory Investigation
Am J Nephrol 2008;28:831–839
(DOI:10.1159/000137683)

Acute Kidney Injury in the Diabetic Rat: Studies in the Isolated Perfused and Intact Kidney

Rosenberger C.a · Khamaisi M.b · Goldfarb M.c · Shina A.b · Shilo V.b · Zilbertrest F.b · Rosen S.d · Heyman S.N.b
aDepartment of Nephrology and Medical Intensive Care, Charité University Clinic, Berlin, Germany; bDepartments of Medicine, Hadassah Hospitals, Mt. Scopus and Ein Kerem and the Hebrew University Medical School, cNephrology Unit, Bikur Holim Hospital, Jerusalem, Israel; dDepartment of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Report: Laboratory Investigation

Received: April 02, 2008
Accepted: April 07, 2008
Published online: June 06, 2008
Issue release date: September 2008

Number of Print Pages: 9
Number of Figures: 4
Number of Tables: 2

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN

Abstract

Background/Aim: Diabetes leads to chronic renal hypoxia and cellular hypoxia response (mediated by hypoxia-inducible factors) and predisposes to acute kidney injury. We studied the impact of acute and chronic hypoxic stress on the development of acute kidney injury in the diabetic rat kidney. Methods: Control (CTR) and streptozotocin (STZ)-diabetic rats were studied following acute medullary hypoxic stress, induced by combinations of radiocontrast and inhibitors of cyclooxygenase and NO synthase. In addition, STZ and CTR kidneys were compared following ex vivo perfusion with oxygenated cell-free medium. Results: The extents of medullary acute tubular injury and renal dysfunction were largely comparable in CTR and STZ-diabetic kidneys in vivo. By contrast, functional deterioration and outer medullary injury were markedly enhanced in STZ kidneys perfused ex vivo. A peculiar collecting duct injury pattern, with cell swelling and detachment, noted in intact STZ kidneys, prominently intensified following isolated perfusion. Conclusions: The diabetic kidney is remarkably resistant to acute hypoxic injury in vivo, possibly due to chronic hypoxia adaptation. Thus, though diabetes predisposes to acute kidney injury in various clinical settings, reduced kidney function does not necessarily imply a greater extent of true tubular damage. The collecting duct injury pattern is an as yet unrecognized feature of early experimental diabetes.

© 2008 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Report: Laboratory Investigation

Received: April 02, 2008
Accepted: April 07, 2008
Published online: June 06, 2008
Issue release date: September 2008

Number of Print Pages: 9
Number of Figures: 4
Number of Tables: 2

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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