Login to MyKarger

New to MyKarger? Click here to sign up.

Login with Facebook

Forgot Password? Reset your password

Authors, Editors, Reviewers

For Manuscript Submission, Check or Review Login please go to Submission Websites List.

Submission Websites List

Institutional Login (Shibboleth)

For the academic login, please select your country in the dropdown list. You will be redirected to verify your credentials.

Table of Contents
Vol. 32, No. 2, 1986
Issue release date: 1986
Section title: Original Paper
Pharmacology 1986;32:90–100
(DOI:10.1159/000138156)

Effects of an Intravenous Infusion of Noradrenaline on the Plasma Concentration of Free and Sulfoconjugated Catecholamines in Anesthetized Dogs

Cuche J.L. · Jondeau G. · Ruget G. · Selz F. · Piga J.C. · Harboun C.
Clinical Research Laboratory, INSERM Unit 27, Hôpital Foch, Suresnes, France

Do you have an account?

Login Information





Contact Information










I have read the Karger Terms and Conditions and agree.



Login Information





Contact Information










I have read the Karger Terms and Conditions and agree.



To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

CHF 38.00 *
EUR 35.00 *
USD 39.00 *

Select

KAB

Buy a Karger Article Bundle (KAB) and profit from a discount!

If you would like to redeem your KAB credit, please log in.


Save over 20% compared to the individual article price.
Learn more

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00


Select

Subscribe

  • Access to all articles of the subscribed year(s) guaranteed for 5 years
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select

* The final prices may differ from the prices shown due to specifics of VAT rules.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: November 12, 1984
Accepted: May 30, 1985
Published online: June 04, 2008
Issue release date: 1986

Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: http://www.karger.com/PHA

Abstract

Exogenous noradrenaline (NA) was infused intravenously at increasing rate from zero (control) to 10, 25, 50, 100, 200 and 600 ng/kg/min during 20 min in anesthetized and ventilated dogs; the mean ( ± SEM) plasma concentration of free NA was increased from 130 ± 23 pg/ml (basal) to 7,826 ± 787 pg/ml. This had no measurable effect on the plasma concentration of dopamine and adrenaline in either free or sulfoconjugated form; a lack of change was also observed in dogs given a 600-ng/kg/min infusion during more than 2 h. The increase of free NA concentration was highly correlated both with the infusion rate, and with the blood pressure. Contrary to expectations, the plasma concentration of NA sulfate decreased in all 5 dogs when plasma NA concentration was progressively increased from basal to about 1,600 pg/ml; beyond this apparently crucial level (i.e. from about 1,600 to 7,826 pg/ml), the response of NA sulfate concentration was erratic, as it was in dogs given a 600-ng/kg/min infusion during more than 2 h. If the response of canine blood pressure is examined in the light of the level of free NA concentration, two mechanisms can be suspected: (l)when the NA level increased from basal to about 1,600 pg/ml, a direct action upon peripheral resistances was likely to be the predominant hypertensive mechanism; (2) beyond about 1,600 pg/ml, a combined effect of NA on both peripheral resistances and cardiac hemodynamics could have a role in the hypertensive process. Thus, a concentration of NA of about 1,600 pg/ml appears to be a landmark for both CA metabolism and circulatory homeostasis. Further studies will have to be carried out to investigate whether this represents the upper physiological concentration in the anesthetized dog.Free and Sulfoconjugated Noradrenaline in Dog’s Plasma

© 1986 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: November 12, 1984
Accepted: May 30, 1985
Published online: June 04, 2008
Issue release date: 1986

Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: http://www.karger.com/PHA


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.