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Vol. 36, Suppl. 1, 1988
Issue release date: 1988
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Pharmacology 1988;36:7–14
(DOI:10.1159/000138415)
Motility

Gastrointestinal Motility: Some Basic Concepts

Sarna S.K. · Otterson M.F.
Departments of Surgery and Physiology, Medical College Wisconsin and Zablocki VA Medical Center, Milwaukee, Wis., USA Pharmacology 1988;36:7–14 (DOI:10.1159/000138415)

Abstract

The spatial and temporal patterns of phasic contractions in the gastrointestinal tract are regulated by a complex interplay between the myogenic, neural and chemical control mechanisms. These contractions are largely responsible for the mixing and propulsive movements of the gut after a meal. In the fasted state, organized groups of contractions called cyclic motor activity and migrating motor complex keep the upper digestive tract clean of residual food and debris. In addition, the small intestine and the colon generate giant migrating contractions which are several-fold stronger than the postprandial phasic contractions and migrate uninterrupted over long distances. The giant migrating contractions are effective in rapid propulsion. The upper small intestine and the antrum generate retrograde giant contractions that generally precede vomiting.

 goto top of outline Author Contacts

Dr. Sushil K. Sarna, Zablocki VA Medical Center, Surgical Research 151, Milwaukee, WI 53295 (USA)


 goto top of outline Article Information

Number of Print Pages : 8


 goto top of outline Publication Details

Pharmacology (International Journal of Experimental and Clinical Pharmacology)

Vol. 36, No. Suppl. 1, Year 1988 (Cover Date: 1988)

Journal Editor: Donnerer J. (Graz), Billingsley M.L. (Hershey, Pa.), Maeyama K. (Matsuyama)
ISSN: 0031–7012 (Print), eISSN: 1423–0313 (Online)

For additional information: http://www.karger.com/PHA


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