Mismatch Negativity: Different Water in the Same RiverPicton T.W. · Alain C. · Otten L. · Ritter W. · Achim A.
aRotman Research Institute, Baycrest Centre for Geriatric Care, University of Toronto, Canada; bInstitute of Cognitive Neuroscience, University of London, England; cDepartment of Neuroscience, Albert Einstein College of Medicine, Bronx, N.Y., USA; dCentre de Neuroscience de la Cognition, Université de Québec à Montréal, Canada
The mismatch negativity (MMN) is a frontal negative deflection in the human event-related potential that typically occurs when a repeating auditory stimulus changes in some manner. The MMN can be elicited by many kinds of stimulus change, varying from simple changes in a single stimulus feature to abstract changes in the relationship between stimuli. The main intracerebral sources for the MMN are located in the auditory cortices of the temporal lobe. Since it occurs whether or not stimuli are being attended, the MMN represents an automatic cerebral process for detecting change. The MMN is clinically helpful in terms of demonstrating disordered sensory processing or disordered memory in groups of patients. Improvements in the techniques for measuring the MMN and in the paradigms for eliciting it will be needed before the MMN can become clinically useful as an objective measurement of such disorders in individual patients.
Terence W. Picton
Rotman Research Institute, Baycrest Centre for Geriatric Care
Toronto, Ontario M6A 2E1 (Canada)
Tel. +1 416 785 2500, ext. 3505, Fax +1 416 785 2862
Number of Print Pages : 29
Number of Figures : 6, Number of Tables : 1, Number of References : 161
Audiology & Neuro-Otology (Basic Research and Clinical Applications)
Vol. 5, No. 3-4, Year 2000 (Cover Date: May-August 2000)
Journal Editor: Manfried Hoke, Münster, Germany
ISSN: 1420–3030 (print), 1421–9700 (Online)
For additional information: http://www.karger.com/journals/aud