Event-related potentials provide an objective index of neurocognitive dysfunction in schizophrenia. Schizophrenia subjects show a decreased mismatch negativity (MMN) amplitude relative to age- and sex-matched controls, along with a characteristic pattern of MMN dysfunction across conditions. Deficits in MMN generation are accompanied by (1) impaired precision of auditory sensory memory performance and (2) an interstimulus-interval-dependent deficit in auditory N1 generation. Similar deficits are observed following systemic or local infusion of N-methyl-D-aspartate (NMDA) antagonists, supporting glutamatergic and phencyclidine/NMDA models of the disorder. Deficits in MMN generation may also be seen following focal cortical damage, especially to the dorsolateral prefrontal cortex. MMN thus provides a useful tool for investigating mechanisms underlying brain dysfunction in schizophrenia.
© 2000 S. Karger AG, Basel
Daniel C. Javitt, MD, PhD
Director, Program in Cognitive Neuroscience and Schizophrenia
Nathan Kline Institute for Psychiatric Research
140 Old Orangeburg Road, Orangeburg, NY 10962 (USA)
Tel. +1 914 398 6534/6546, Fax +1 914 398 6545, E-Mail firstname.lastname@example.org
Number of Print Pages : 9
Number of Figures : 4, Number of Tables : 0, Number of References : 93
Audiology & Neuro-Otology (Basic Research and Clinical Applications)
Vol. 5, No. 3-4, Year 2000 (Cover Date: May-August 2000)
Journal Editor: Manfried Hoke, Münster, Germany
ISSN: 1420–3030 (print), 1421–9700 (Online)
For additional information: http://www.karger.com/journals/aud
Article / Publication Details
Published online: 5/19/2000
Issue release date: May–August 2000
Number of Print Pages: 9
Number of Figures: 4
Number of Tables: 0
ISSN: 1420-3030 (Print)
eISSN: 1421-9700 (Online)
For additional information: http://www.karger.com/AUD
Copyright / Drug Dosage
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.