Event-related potentials provide an objective index of neurocognitive dysfunction in schizophrenia. Schizophrenia subjects show a decreased mismatch negativity (MMN) amplitude relative to age- and sex-matched controls, along with a characteristic pattern of MMN dysfunction across conditions. Deficits in MMN generation are accompanied by (1) impaired precision of auditory sensory memory performance and (2) an interstimulus-interval-dependent deficit in auditory N1 generation. Similar deficits are observed following systemic or local infusion of N-methyl-D-aspartate (NMDA) antagonists, supporting glutamatergic and phencyclidine/NMDA models of the disorder. Deficits in MMN generation may also be seen following focal cortical damage, especially to the dorsolateral prefrontal cortex. MMN thus provides a useful tool for investigating mechanisms underlying brain dysfunction in schizophrenia.
© 2000 S. Karger AG, Basel
Daniel C. Javitt, MD, PhD
Director, Program in Cognitive Neuroscience and Schizophrenia
Nathan Kline Institute for Psychiatric Research
140 Old Orangeburg Road, Orangeburg, NY 10962 (USA)
Tel. +1 914 398 6534/6546, Fax +1 914 398 6545, E-Mail email@example.com
Number of Print Pages : 9
Number of Figures : 4, Number of Tables : 0, Number of References : 93
Audiology & Neuro-Otology (Basic Research and Clinical Applications)
Vol. 5, No. 3-4, Year 2000 (Cover Date: May-August 2000)
Journal Editor: Manfried Hoke, Münster, Germany
ISSN: 1420–3030 (print), 1421–9700 (Online)
For additional information: http://www.karger.com/journals/aud
Article / Publication Details
Published online: 5/19/2000
Issue release date: May–August 2000
Number of Print Pages: 9
Number of Figures: 4
Number of Tables: 0
ISSN: 1420-3030 (Print)
eISSN: 1421-9700 (Online)
For additional information: http://www.karger.com/AUD
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