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Vol. 47, No. 4, 1993
Issue release date: 1993
Section title: Original Paper
Pharmacology 1993;47:217–222
(DOI:10.1159/000139100)

Effects of Piracetam on N-Methyl-D-Aspartate Receptor Properties in the Aged Mouse Brain

Cohen S.A. · Mutter W.E.
Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, FRG

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 11/9/1992
Accepted: 2/14/1993
Published online: 6/10/2008
Issue release date: 1993

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: http://www.karger.com/PHA

Abstract

Subchronic treatment of aged mice with piracetam (500 mg/kg p.o. for 14 days) elevates N-methyl-D-aspartate (NMDA) receptor density by about 20% and normalizes the enhanced affinity of L-glutamate for the NMDA receptor. Since deficits at the level of the NMDA receptor might be one of the mechanisms underlying age-associated cognitive impairment, the effects reported for piracetam may be relevant for the cognition-enhancing properties of this drug.

© 1993 S. Karger AG, Basel


  

Author Contacts

Prof. Dr. W.E. Müller, Abteilung Psychopharmakologie, Zentralinstitut für Seelische Gesundheit, D-68159 Mannheim (BRD)

  

Article Information

Received: November 9, 1992
Accepted: February 14, 1993
Published online: June 10, 2008
Number of Print Pages : 6

  

Publication Details

Pharmacology (International Journal of Experimental and Clinical Pharmacology)

Vol. 47, No. 4, Year 1993 (Cover Date: 1993)

Journal Editor: Donnerer J. (Graz), Billingsley M.L. (Hershey, Pa.), Maeyama K. (Matsuyama)
ISSN: 0031–7012 (Print), eISSN: 1423–0313 (Online)

For additional information: http://www.karger.com/PHA


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 11/9/1992
Accepted: 2/14/1993
Published online: 6/10/2008
Issue release date: 1993

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: http://www.karger.com/PHA


Copyright / Drug Dosage

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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