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Table of Contents
Vol. 49, No. 3, 1994
Issue release date: 1994
Section title: Original Papers
Pharmacology 1994;49:144–150
(DOI:10.1159/000139228)

Antiulcer Effect of Naringin on Gastric Lesions Induced by Ethanol in Rats

Martin M.J.a · Marhuenda E.a · Pérez-Guerrero C.a · Franco J.M.b
aDepartamento de Farmacia y Tecnologia Farmacéutica, Laboratorio de Farmacodinamia, Facultad de Farmacia, y bDepartamento de Ingenieria Química, Facultad de Químicas, Universidad de Sevilla, España

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Article / Publication Details

First-Page Preview
Abstract of Original Papers

Received: July 23, 1993
Accepted: February 02, 1994
Published online: June 10, 2008
Issue release date: 1994

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: http://www.karger.com/PHA

Abstract

This study was designed to determine the gastroprotective properties of naringin on and the involvement of endogenous prostaglandins in mucosal injury produced by absolute ethanol. Oral pretreatment with the highest dose of naringin (400 mg/kg), 60 min before absolute ethanol was the most effective antiulcer treatment. Subcutaneous administration of indometacin (10 mg/kg) to the animals treated with naringin (400 mg/kg) partially inhibited gastric protection, but the prostaglandin E2 determination did not show any increase in prostanoid levels. The contents of gastric mucus and total proteins were not significantly modified. Naringin-treated rats showed a marked increase in hexosamine levels, but this increase was less in animals pretreated with indometacin. These results show that naringin has a ‘cytoprotective’ effect against ethanol injury in the rat, but this property appears to be mediated by non-prostaglandin-dependent mechanisms.

© 1994 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Papers

Received: July 23, 1993
Accepted: February 02, 1994
Published online: June 10, 2008
Issue release date: 1994

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: http://www.karger.com/PHA


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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