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Table of Contents
Vol. 188, No. 4, 2008
Issue release date: October 2008
Section title: Review
Cells Tissues Organs 2008;188:333–346
(DOI:10.1159/000139772)

Fibrin: A Natural Biodegradable Scaffold in Vascular Tissue Engineering

Shaikh F.M.a, b · Callanan A.b · Kavanagh E.G.a, b · Burke P.E.a, b · Grace P.A.a, b · McGloughlin T.M.b
aDepartment of Surgery, Mid-Western Regional Hospital, and bCentre for Applied Biomedical Engineering Research and MSSI, University of Limerick, Limerick, Ireland

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Article / Publication Details

First-Page Preview
Abstract of Review

Accepted: 1/7/2008
Published online: 6/13/2008
Issue release date: October 2008

Number of Print Pages: 14
Number of Figures: 1
Number of Tables: 2

ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)

For additional information: http://www.karger.com/CTO

Abstract

Arterial occlusive disease remains a major health issue in the developed world and a rapidly growing problem in the developing world. Although a growing number of patients are now being effectively treated with minimally invasive techniques, there remains a tremendous pressure on the vascular community to develop a synthetic small-diameter vascular graft with improved long-term patency rates. The field of tissue engineering offers an exciting alternative in the search for living organ replacement structures. Several methodologies have emerged for constructing blood vessel replacements with biological functionality. Common strategies include cell-seeded biodegradable synthetic scaffolds, cell self-assembly, cell-seeded gels and xenogeneic acellular materials. A wide range of materials are being investigated as potential scaffolds for vascular tissue engineering applications. Some are commercialised and others are still in development. Recently, researchers have studied the role of fibrin gel as a three-dimensional scaffold in vascular tissue engineering. This overview describes the properties of fibrin gel in vascular tissue engineering and highlights some recent progress and difficulties encountered in the development of cell fibrin scaffold technology.

© 2008 S. Karger AG, Basel


  

Author Contacts

Dr. Tim M. McGloughlin
Centre for Applied Biomedical Engineering Research
University of Limerick
IE–Limerick (Ireland)
Tel. +353 61 202 217, Fax +353 61 202 944, E-Mail tim.mcgloughlin@ul.ie

  

Article Information

Accepted after revision: January 7, 2008
Published online: June 13, 2008
Number of Print Pages : 14
Number of Figures : 1, Number of Tables : 2, Number of References : 118

  

Publication Details

Cells Tissues Organs (in vivo, in vitro)

Vol. 188, No. 4, Year 2008 (Cover Date: October 2008)

Journal Editor: Denker H.-W. (Essen), English A.W. (Atlanta, Ga.)
ISSN: 1422–6405 (Print), eISSN: 1422–6421 (Online)

For additional information: http://www.karger.com/CTO


Article / Publication Details

First-Page Preview
Abstract of Review

Accepted: 1/7/2008
Published online: 6/13/2008
Issue release date: October 2008

Number of Print Pages: 14
Number of Figures: 1
Number of Tables: 2

ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)

For additional information: http://www.karger.com/CTO


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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