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Vol. 112, No. 2, 2009
Issue release date: December 2008
Section title: Original Research
Cardiology 2009;112:98–106
(DOI:10.1159/000141462)

Intracoronary Delivery of Bone Marrow Cells to the Acutely Infarcted Myocardium

Optimization of the Delivery Technique

Meluzín J.a · Vlašín M.b · Groch L.a · Mayer J.c · Křen L.d · Raušer P.b · Tichý B.c · Horňáček I.a · Sitar J.a · Palša S.c · Klabusay M.c · Kořístek Z.c · Doubek M.c · Pospíšilová Š.c · Lexmaulová L.b · Dušek L.e
a1st Department of Internal Medicine/Cardioangiology, St. Anna Hospital, ICRC, Masaryk University, bDogs and Cats Clinic, University of Veterinary and Pharmaceutical Science, cDepartment of Internal Medicine/Hematooncology, FH Brno, Masaryk University, dDepartment of Pathology, Masaryk University, and eCenter of Biostatistics and Analyses, Masaryk University, Brno, Czech Republic

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Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: 11/22/2007
Accepted: 2/28/2008
Published online: 6/27/2008
Issue release date: December 2008

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 2

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD

Abstract

Objectives: Intracoronary cell transplantation during catheter balloon inflations may be associated with adverse events. We studied the effectiveness of an alternative transplantation technique – intracoronary cell infusion. Methods: Fourteen pigs, which had survived acute myocardial infarction, were randomized into 2 treatment groups and 2 controls. Three days after infarction, 12 pigs underwent allogeneic intracoronary mononuclear bone marrow cell transplantation using either the standard technique (short-term cell injections during repeat balloon inflations, technique A, n = 6) or continuous intracoronary cell infusion without balloon inflations (technique B, n = 6). Implanted cells were stained with fluorescent dye. After transplantation, the pigs were euthanized and myocardial samples were analyzed by fluorescent microscopy. Results: The mean numbers of fluorescently labeled bone marrow cells in the infarction border zone, in the infarction mid-area and in the center of myocardial infarction were 84, 72 and 55 using technique A, and 29, 57 and 46 using technique B, respectively. The mean cell retention in the infarction border zone of 84 cells for technique A and 29 cells for technique B differed significantly (p = 0.034, two-tailed t test). Conclusion: The continuous intracoronary cell infusion technique is a less efficient cell delivery technique as compared with the standard technique using repeat intracoronary balloon inflations.

© 2008 S. Karger AG, Basel


  

Author Contacts

Jaroslav Meluzín, MD
1st Department of Internal Medicine/Cardioangiology
St. Anna Hospital, Pekařská 53
CZ–656 91 Brno (Czech Republic)
Tel. +42 054 318 2224, Fax +42 054 318 2205, E-Mail jaroslav.meluzin@fnusa.cz

  

Article Information

Received: November 22, 2007
Accepted after revision: February 28, 2008
Published online: June 27, 2008
Number of Print Pages : 9
Number of Figures : 3, Number of Tables : 2, Number of References : 30

  

Publication Details

Cardiology (International Journal of Cardiovascular Medicine, Surgery, Pathology and Pharmacology)

Vol. 112, No. 2, Year 2009 (Cover Date: December 2008)

Journal Editor: Borer J.S. (New York, N.Y.)
ISSN: 0008–6312 (Print), eISSN: 1421–9751 (Online)

For additional information: http://www.karger.com/CRD


Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: 11/22/2007
Accepted: 2/28/2008
Published online: 6/27/2008
Issue release date: December 2008

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 2

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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