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Vol. 2, No. 2, 2008
Issue release date: May – August 2008
Open Access Gateway
Case Rep Gastroenterol 2008;2:238–243
(DOI:10.1159/000142739)
Published: July 2008

A Pancreatic Polypeptide-Producing Pancreatic Tumor Causing WDHA Syndrome

Amrilleva V.a · Slater E.P.a · Waldmann J.a · Bonorden D.b · Fendrich V.a
Departments of aSurgery and bGastroenterology, Philipps University Marburg, Marburg, Germany

Abstract

We report the case of a 46-year-old female patient with WDHA (watery diarrhea/hypokalemia/achlorhydria) syndrome caused by a pancreatic polypeptide-producing tumor in the head of the pancreas. Whereas VIP and other pancreatic endocrine hormones were in the normal range, only serum levels of pancreatic polypeptide were elevated. Imaging studies identified a pancreatic tumor in the head of the gland. After laparotomy, the tumor of 3 cm in size was enucleated. Final pathology documented a pancreatic endocrine tumor with immunohistochemical staining demonstrating the presence of pancreatic polypeptide. The patient remained cured after a follow-up of more than three years. The present case illustrates that, although rare, WDHA syndrome may be associated with a pancreatic polypeptide-secreting endocrine tumor of the pancreas.

 goto top of outline Author Contacts

Volker Fendrich, MD
Department of Surgery, Philipps University Marburg
Baldingerstrasse
DE–35043 Marburg (Germany)
Tel. +49 6421 2866441, Fax +49 6421 2862105, E-Mail fendrich@med.uni-marburg.de


 goto top of outline Article Information

Published online: July 9, 2008
Number of Print Pages : 6
Number of Figures : 2, Number of Tables : 1, Number of References : 15


 goto top of outline Publication Details

Case Reports in Gastroenterology

Vol. 2, No. 2, Year 2008 (Cover Date: July 2008)

Journal Editor: Urrutia R. (Rochester, Minn.)
ISSN: NIL (Print), eISSN: 1662–0631 (Online)

For additional information: http://www.karger.com/CRG


Open Access License / Drug Dosage

Open Access License: This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.
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