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Table of Contents
Vol. 16, No. 1-2, 2009
Issue release date: October 2008
Section title: Paper
Free Access
J Mol Microbiol Biotechnol 2009;16:38–52

Genomic View of Energy Metabolism in Ralstonia eutropha H16

Cramm R.
Institut für Biologie, Humboldt-Universität zu Berlin, Berlin, Germany
email Corresponding Author

Rainer Cramm

Institut für Biologie/Mikrobiologie, Humboldt-Universität zu Berlin

Chausseestrasse 117

DE–10115 Berlin (Germany)

Tel. +49 30 2093 8111, Fax +49 30 2093 8102, E Mail rainer.cramm@rz.hu-berlin.de

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Ralstonia eutropha is a strictly respiratory facultative lithoautotrophic β-proteobacterium. In the absence of organic substrates, H2 and CO2 are used as sole sources of energy and carbon. In the absence of oxygen, the organism can respire by denitrification. The recent determination of the complete genome sequence of strain H16 provides the opportunity to reconcile the results of previous physiological and biochemical studies in light of the coding capacity. These analyses revealed genes for several isoenzymes, permit assignment of well-known physiological functions to previously unidentified genes, and suggest the presence of unknown components of energy metabolism. The respiratory chain is fueled by two NADH dehydrogenases, two uptake hydrogenases and at least three formate dehydrogenases. The presence of genes for five quinol oxidases and three cytochrome oxidases indicates that the aerobic respiration chain adapts to varying concentrations of dioxygen. Several additional components may act in balancing or dissipation of redox energy. Paralogous sets of nitrate reductase and nitric oxide reductase genes result in enzymatic redundancy for denitrification.

© 2008 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: October 29, 2008
Issue release date: October 2008

Number of Print Pages: 15
Number of Figures: 1
Number of Tables: 1

ISSN: 1464-1801 (Print)
eISSN: 1660-2412 (Online)

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