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Vol. 94, No. 3, 2008
Issue release date: October 2008
Section title: Systematic Review and Meta-Analysis
Neonatology 2008;94:176–182
(DOI:10.1159/000143397)

Resuscitation of Newborn Infants with 21% or 100% Oxygen: An Updated Systematic Review and Meta-Analysis

Saugstad O.D. · Ramji S. · Soll R.F. · Vento M.
aDepartment of Paediatric Research, Rikshospitalet Medical Centre, University of Oslo, Oslo, Norway; bDepartment of Paediatrics, Maulana Azad Medical College, New Delhi, India; cDepartment of Pediatrics, University of Vermont College of Medicine, Burlington, Vt., USA; dServicio de Neonatologia, Hospital Universitario Materno-Infantil, La Fe, Valencia, Spain

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Article / Publication Details

First-Page Preview
Abstract of Systematic Review and Meta-Analysis

Published online: 7/9/2008

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 2

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO

Abstract

Background: The issue of whether 21% O2 is more effective than 100% O2 for resuscitation of newborn infants remains controversial. Objectives: We have updated the systematic review and meta-analysis including all studies reporting resuscitation of newborn infants with 21 or 100% O2. Methods: Randomized or quasi-randomized studies of depressed newborn infants resuscitated with 21 or 100% O2 with or without masking of treatment were considered for inclusion. The outcomes of interest included neonatal mortality and hypoxic ischemic encephalopathy. Results: Ten studies fulfilled the inclusion criteria. Of these, 6 studies were identified as being strictly randomized. In total, 1,082 infants were allocated to resuscitation with 21% O2 and 1,051 infants with 100% O2. The risk of neonatal mortality was reduced in the 21% O2 group compared to the 100% O2 group both in the analysis of all studies (typical RR 0.69, 95% CI 0.54, 0.88) and in the analysis of strictly randomized studies (typical RR 0.32, 95% CI 0.12, 0.84). A trend toward a decrease in the risk of hypoxic ischemic encephalopathy stage 2 and 3 was noted with resuscitation in 21% O2 in the analysis of all studies (typical RR 0.88, 95% CI 0.72, 1.08). Conclusions: There is a significant reduction in the risk of neonatal mortality and a trend towards a reduction in the risk of severe hypoxic ischemic encephalopathy in newborns resuscitated with 21% O2.


  

Author Contacts

Prof. O.D. Saugstad, MD
Department of Paediatric Research, Rikshospitalet Medical Centre, University of Oslo
NO–0027 Oslo (Norway)
Tel. +47 2307 2790 or +47 2307 2794, Fax +47 2307 2780
E-Mail odsaugstad@rr-research.no

  

Article Information

Published online: July 9, 2008
Number of Print Pages : 7
Number of Figures : 2, Number of Tables : 2, Number of References : 30

  

Publication Details

Neonatology (Fetal and Neonatal Research)

Vol. 94, No. 3, Year 2008 (Cover Date: October 2008)

Journal Editor: Halliday H.L. (Belfast), Speer C.P. (Würzburg)
ISSN: 1661–7800 (Print), eISSN: 1661–7819 (Online)

For additional information: http://www.karger.com/NEO


Article / Publication Details

First-Page Preview
Abstract of Systematic Review and Meta-Analysis

Published online: 7/9/2008

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 2

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO


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