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Table of Contents
Vol. 60, No. 3, 2008
Issue release date: August 2008
Section title: Original Paper
Eur Neurol 2008;60:149–154
(DOI:10.1159/000144086)

Cognitive Impairment in Late-Onset Depression

Limited to a Decrement in Information Processing Resources?

Delaloye C. · Baudois S. · de Bilbao F. · Dubois Remund C. · Hofer F. · Lamon M. · Ragno Paquier C. · Weber K. · Herrmann F.R. · Giardini U. · Giannakopoulos P.
aDivision of Geriatric Psychiatry and bDepartment of Rehabilitation and Geriatrics, University Hospitals of Geneva, and cFaculty of Psychology and Educational Sciences, University of Geneva, Geneva, and dService of Old Age Psychiatry, University Hospitals of Lausanne, Lausanne, Switzerland

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/13/2007
Accepted: 2/12/2008
Published online: 7/14/2008

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 2

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE

Abstract

Background: While cognitive dysfunction in late-onset depression (LOD) is common, the nature and determinants of this impairment are heterogeneous. It has been suggested that neuropsychological decrements in LOD patients might result from a deficit in processing resources. In order to address this issue, we analyzed processing resources in LOD to see if their decrease explains higher-level cognition (episodic memory and naming capacity) deficits. Methods: Measures of processing speed, working memory, inhibition, episodic memory and naming capacity were administered to 14 LOD inpatients and 14 controls. Results: The LOD patients performed significantly worse than the controls in all domains except for inhibition. Hierarchical regression analyses showed that naming capacity impairment was totally mediated by processing speed and working memory, whereas episodic memory dysfunction was only partially mediated by working memory. Conclusion: The reduction in certain processing resources (working memory, processing speed) in late-onset depressed patients appears to mediate impairments in episodic memory and naming capacity. However, episodic memory impairment cannot only be explained by processing resource decrement in LOD patients, suggesting that a primary episodic memory dysfunction is present in this condition.


  

Author Contacts

Dr Christophe Delaloye
Service de Psychiatrie Gériatrique, Hôpitaux Universitaires de Genève
2 Chemin du Petit-Bel-Air
CH–1225 Chêne-Bourg (Switzerland)
Tel. +41 22 305 51 30, Fax +41 22 305 50 44, E-Mail Christophe.Delaloye@hcuge.ch

  

Article Information

Received: July 13, 2007
Accepted: February 12, 2008
Published online: July 14, 2008
Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 2, Number of References : 50

  

Publication Details

European Neurology

Vol. 60, No. 3, Year 2008 (Cover Date: August 2008)

Journal Editor: Bogousslavsky J. (Montreux)
ISSN: 0014–3022 (Print), eISSN: 1421–9913 (Online)

For additional information: http://www.karger.com/ENE


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/13/2007
Accepted: 2/12/2008
Published online: 7/14/2008

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 2

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE


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