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Vol. 96, No. 3, 1976
Issue release date: 1976
Section title: Paper
Acta Anatomica 1976;96:356–365
(DOI:10.1159/000144686)

Effects of hypophysectomy and short- and long-term propylthiouracil treatment on the rat thyroid

Transmission and scanning electron-microscopic study

Gaal J.M. · Kovacs K. · Sellers E.A.
Department of Pharmacology, University of Toronto and Department of Pathology, St. Michael’s Hospital, University of Toronto, Toronto, Canada

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: 9/1/1975
Published online: 7/9/2008
Issue release date: 1976

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0

ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)

For additional information: http://www.karger.com/CTO

Abstract

The follicular architecture of the thyroid gland of the rat following experimentally induced states of hypo- and hyperactivity was investigated by scanning electron microscopy and the findings correlated with both light and transmission electron-microscopic observations. By scanning electron microscopy, the microvilli on the apical surfaces of the follicular cells showed the most striking changes; following hypophysectomy, the cells were flattened and the microvilli had decreased in both size and number, whereas following propylthiouracil (PTU) administration the epithelial cells were enlarged, and marked hyperplasia and hypertrophy of the microvilli was present. Of particular interest is that the changes observed following PTU appeared to be identical in short- and long-term PTU-treated rats. Similarly, the heterogeneity of the follicular cells observed within the follicles was maintained under the various experimental conditions. Although the functional significance of these observations is not quite clear, it appears justifiable to assume that a reduction of luminal surface area of the follicular epithelial cell may hinder, whereas an increase may facilitate transport process across the apical cell membrane.

© 1976 S. Karger AG, Basel


  

Author Contacts

J.M. Gaal, Department of Pharmacology, University of Toronto, Toronto, Ont. M5S1A8 (Canada)

  

Article Information

Received: September 1, 1975
Published online: July 09, 2008
Number of Print Pages : 10

  

Publication Details

Cells Tissues Organs (in vivo, in vitro)

Vol. 96, No. 3, Year 1976 (Cover Date: 1976)

Journal Editor: Denker H.-W. (Essen), English A.W. (Atlanta, Ga.)
ISSN: 1422–6405 (Print), eISSN: 1422–6421 (Online)

For additional information: http://www.karger.com/CTO


Article / Publication Details

First-Page Preview
Abstract of Paper

Received: 9/1/1975
Published online: 7/9/2008
Issue release date: 1976

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0

ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)

For additional information: http://www.karger.com/CTO


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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