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Vol. 114, No. 1, 1982
Issue release date: 1982
Section title: Paper
Acta Anatomica 1982;114:41–57
(DOI:10.1159/000145577)

Response of Pericytes to Thermal Lesion in the Inguinal Fat Pad of 10-Day-Old Rats

Richardson R.L. · Hausman G.J. · Campion D.R.
Richard B. Russell Agricultural Research Center, USDA, ARS, Agricultural Research Service, Athens, Ga., USA

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: 2/10/1982
Accepted: 4/1/1982
Published online: 7/10/2008
Issue release date: 1982

Number of Print Pages: 17
Number of Figures: 0
Number of Tables: 0

ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)

For additional information: http://www.karger.com/CTO

Abstract

The response of capillary pericytes to thermal lesion in the inguinal fat pad of 10-day-old rats was observed with the light and electron microscope. Samples were taken from the necrotic area and the immediately surrounding tissue at various time intervals from 1 h to 10 days post-lesion. The initial physical disruption and swelling of the capillary resulted in the liberation of some pericytes near the necrotic zone. Most pericytes remained, however, in the basal lamina and went through a period of activation that peaked at 48 h. Pericyte activation consisted of a noticeable increase in rough endoplasmic reticulum with the cisternae containing granular, electron-opaque material. There was evidence of migration of these activated cells from the capillary basal lamina between 24 and 72 h. By 72 h, fibroblast-like cells possessing different nuclear and cytoplasmic morphology were oriented along distinct bands of extracellular fibrin and necrotic tissue. These cells produced limited amounts of collagen. Differentiation into immature adipocytes occurred 5 days after the lesion. Small, unilocular adipocytes were located in the necrotic zone by 7 days. Complete restoration of the lesion area was accomplished by 10 days. It is proposed that pericytes act as a reserve cell in the recovery of the rat inguinal fat pad after thermal lesion.

© 1982 S. Karger AG, Basel


  

Author Contacts

R.L. Richardson, USDA – Russell Research Center, PO Box 5677, Athens, GA 30613 (USA)

  

Article Information

Received: February 10, 1982
Accepted: April 1, 1982
Published online: July 10, 2008
Number of Print Pages : 17

  

Publication Details

Cells Tissues Organs (in vivo, in vitro)

Vol. 114, No. 1, Year 1982 (Cover Date: 1982)

Journal Editor: Denker H.-W. (Essen), English A.W. (Atlanta, Ga.)
ISSN: 1422–6405 (Print), eISSN: 1422–6421 (Online)

For additional information: http://www.karger.com/CTO


Article / Publication Details

First-Page Preview
Abstract of Paper

Received: 2/10/1982
Accepted: 4/1/1982
Published online: 7/10/2008
Issue release date: 1982

Number of Print Pages: 17
Number of Figures: 0
Number of Tables: 0

ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)

For additional information: http://www.karger.com/CTO


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