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Vol. 8, No. 6, 1999
Issue release date: November–December 1999
Section title: Paper
Biol Signals Recept 1999;8:360–365
(DOI:10.1159/000014609)

Co-Localization of Epithelial Sodium Channels and Glutamate Receptors in Single Taste Cells

Lin W. · Kinnamon S.C.
aDepartment of Anatomy and Neurobiology, Colorado State University, Fort Collins, Colo., and bRocky Mountain Taste and Smell Center, University of Colorado Health Sciences Center, Denver, Colo., USA

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 11/29/1999

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 0

ISSN: 1424-862X (Print)
eISSN: 1424-8638 (Online)

For additional information: http://www.karger.com/NSG

Abstract

Umami taste is elicited by monosodium glutamate (MSG), a compound consisting of two potent taste stimuli, Na+ and glutamate. In rat fungiform taste cells, amiloride-sensitive epithelial sodium channels (ENaCs) mediate Na+ transduction, while glutamate is transduced by a combination of ionotropic and metabotropic glutamate receptors. We used giga-seal whole-cell recording to determine if responses to glutamate and Na+ occur in the same taste cells. Approximately 68% of the cells tested responded to amiloride, indicating that they express functional ENaCs. Responses to glutamate occurred in about 58% of the cells tested. Interestingly, responses to glutamate occurred in the subset of cells that also responded to amiloride, indicating that glutamate receptors are located preferentially in the same taste cells that also express ENaCs. Further experiments showed that amiloride did not suppress responses to glutamate under voltage-clamp conditions. Taken together, the data suggest that although ENaCs are not involved directly in glutamate transduction, their co-localization with glutamate receptors provides a substrate for the cellular integration of these independent pathways.


  

Author Contacts

Dr. Weihong Lin
Department of Anatomy and Neurobiology
Colorado State University
Fort Collins, CO 80523 (USA)
Tel. +1 970 491 3801, Fax +1 970 491 7907

  

Article Information

Number of Print Pages : 6
Number of Figures : 3, Number of Tables : 0, Number of References : 25

  

Publication Details

Biological Signals and Receptors

Vol. 8, No. 6, Year 1999 (Cover Date: November-December 1999)

Journal Editor: S.F. Pang, Hong Kong; P.A. Ward, Ann Arbor, Mich.; D.P. Cardinali, Buenos Aires
ISSN: 1422–4933 (print), 1422–4992 (Online)

For additional information: http://www.karger.com/journals/bsi


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 11/29/1999

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 0

ISSN: 1424-862X (Print)
eISSN: 1424-8638 (Online)

For additional information: http://www.karger.com/NSG


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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