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Vol. 9, No. 1, 2000
Issue release date: January–February 2000
Section title: Original Paper
Biol Signals Recept 2000;9:21–28
(DOI:10.1159/000014619)

The Effect of Protein Kinase C Activation on Gz-Mediated Regulation of Type 2 and 6 Adenylyl Cyclases

Ho M.K.C. · Chan J.S.C. · Yung L.Y. · Wong Y.H.
Department of Biology and Biotechnology Research Institute, Hong Kong University of Science and Technology, Hong Kong, China

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 2/23/2000

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 0

ISSN: 1424-862X (Print)
eISSN: 1424-8638 (Online)

For additional information: http://www.karger.com/NSG

Abstract

Three serine-to-alanine mutants of the α subunit of the heterotrimeric G protein Gzz) were examined for their signaling properties in the presence of phorbol ester treatment. All three αz mutants resembled wild-type αz in their abilities to inhibit αs-stimulated type 6 adenylyl cyclase (AC6) and phorbol ester treatment reduced their magnitudes of inhibition. Depending on the permissive condition, the βγ-mediated stimulation of type 2 adenylyl cyclase (AC2) was differentially regulated by αz and the three mutants. Mutation of Ser27 but not Ser16 of αz affected the efficient release of βγ subunits upon receptor activation and abolished the stimulation of phosphorylated but not αs-stimulated AC2.


  

Author Contacts

Yung H. Wong
Department of Biology and Biotechnology Research Institute
Hong Kong University of Science and Technology
Clear Water Bay, Kowloon, Hong Kong (China)
Tel. +852 2358 7328, Fax +852 2358 1559, E-Mail boyung@ust.hk

  

Article Information

Received: Received: March 11, 1999
Accepted: May 3, 1999
Number of Print Pages : 8
Number of Figures : 4, Number of Tables : 0, Number of References : 28

  

Publication Details

Biological Signals and Receptors

Vol. 9, No. 1, Year 2000 (Cover Date: January-February 2000)

Journal Editor: S.F. Pang, Hong Kong; P.A. Ward, Ann Arbor, Mich.; D.P. Cardinali, Buenos Aires
ISSN: 1422–4933 (print), 1422–4992 (Online)

For additional information: http://www.karger.com/journals/bsi


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 2/23/2000

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 0

ISSN: 1424-862X (Print)
eISSN: 1424-8638 (Online)

For additional information: http://www.karger.com/NSG


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