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Vol. 138, No. 3, 1990
Issue release date: 1990
Section title: Paper
Acta Anatomica 1990;138:246–253
(DOI:10.1159/000146947)

Defective Ensheathment of Motoric Nerves in the Splotch Mutant Mouse

Franz T.
Anatomisches Institut, Abteilung für Neuroanatomie, Universitäts-Krankenhaus Eppendorf, Hamburg, BRD

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: 9/1/1989
Accepted: 10/19/1989
Published online: 7/17/2008

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)

For additional information: http://www.karger.com/CTO

Abstract

Mouse embryos, homozygous for mutations at the Splotch locus, are afflicted with spina bifida and disturbances of neural-crest-derived tissues, e.g. spinal ganglia and pigment cells. The development of Schwann cells is affected in homozygotes to a varying degree along the rostrocaudal axis. In cervical motoric roots, nerves are associated with apparently normal Schwann cells. At the thoracic level, nerve-associated cells become more scarce and resemble the surrounding mesenchymal cells. They are not enveloped by a basal lamina and frequently show wide gaps between neighbouring cells. Lumbar motoric roots are mostly devoid of any associated cells. The Splotch mutant embryo is proposed to be a new animal model for the study of peripheral nerve ensheathment. The implications for Schwann-cell-mediated axon guidance are discussed.


  

Author Contacts

Thomas Franz, Anatomisches Institut, Abteilung für Neuroanatomie, Universitäts-Krankenhaus Eppendorf, Martinistrasse 52, D-2000 Hamburg 20 (FRG)

  

Article Information

Received: September 1, 1989
Accepted: October 19, 1989
Published online: July 17, 2008
Number of Print Pages : 8

  

Publication Details

Cells Tissues Organs (in vivo, in vitro)

Vol. 138, No. 3, Year 1990 (Cover Date: 1990)

Journal Editor: Denker H.-W. (Essen), English A.W. (Atlanta, Ga.)
ISSN: 1422–6405 (Print), eISSN: 1422–6421 (Online)

For additional information: http://www.karger.com/CTO


Article / Publication Details

First-Page Preview
Abstract of Paper

Received: 9/1/1989
Accepted: 10/19/1989
Published online: 7/17/2008

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)

For additional information: http://www.karger.com/CTO


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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