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Vol. 153, No. 2, 1995
Issue release date: 1995
Section title: Original Paper
Acta Anatomica 1995;153:119–126
(DOI:10.1159/000147722)

Innervation of the Human Vaginal Mucosa as Revealed by PGP 9.5 Immunohistochemistry

Hilliges M.a,b · Falconer C.c · Ekman-Ordeberg G.d · Johansson O.a
aExperimental Dermatology Unit, Department of Neuroscience, Karolinska Institute, Stockholm, bDepartment of Oral Histology and Cell Biology, School of Dentistry, Karolinska Institute, Huddinge, cDepartment of Gynaecology and Obstetrics, Danderyds Sjukhus, Danderyd, dDepartment of Gynaecology and Obstetrics, Karolinska Sjukhuset, Stockholm, Sweden

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 1/5/1995
Accepted: 4/25/1995
Published online: 7/17/2008
Issue release date: 1995

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)

For additional information: http://www.karger.com/CTO

Abstract

In order to obtain a description of the innervation of the vaginal wall we employed an antiserum against the general neuronal marker, protein gene product 9.5, on normal human vaginal mucosa. Specimens were taken from the anterior and posterior fornices, from the anterior vaginal wall at the bladder neck level and from the introitus vaginae region, and then processed for indirect immunohistochemistry. All regions studied revealed a profound innervation, although regional differences were noted. The more distal areas of the vaginal wall had more nerve fibers compared to the more proximal parts. Also, biopsies from the anterior wall generally were more densely innervated than the posterior wall. Some large nerve coils were observed in lamina propria of the anterior wall as well as gatherings of thick-walled medium-sized blood vessels. Free intraepithelial nerve endings were only detected in the introitus vaginae region. These fibers were very thin, always varicose and could be observed just a few cell layers from the surface. In this part of the vagina, protein gene product 9.5 anti¬bodies also stained cells within the basal parts of the epithelium. These cells were also neurone-specific enolase positive and resembled, from a morphological point of view, Merkel cells.

© 1995 S. Karger AG, Basel


  

Author Contacts

Olle Johansson, Experimental Dermatology Unit, Department of Neuroscience, Karolinska Institute, 171 77 Stockholm (Sweden)

  

Article Information

Received: January 5, 1995
Accepted: April 25, 1995
Published online: July 17, 2008
Number of Print Pages : 8

  

Publication Details

Cells Tissues Organs (in vivo, in vitro)

Vol. 153, No. 2, Year 1995 (Cover Date: 1995)

Journal Editor: Denker H.-W. (Essen), English A.W. (Atlanta, Ga.)
ISSN: 1422–6405 (Print), eISSN: 1422–6421 (Online)

For additional information: http://www.karger.com/CTO


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 1/5/1995
Accepted: 4/25/1995
Published online: 7/17/2008
Issue release date: 1995

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)

For additional information: http://www.karger.com/CTO


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