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Vol. 21, No. 6, 2008
Issue release date: October 2008
Section title: Original Paper
Skin Pharmacol Physiol 2008;21:306–311
(DOI:10.1159/000148223)

Skin Tolerance of a New Bath Oil Containing St. John’s Wort Extract

Reuter J.a · Huyke C.a · Scheuvens H.a · Ploch M.c · Neumann K.d · Jakob T.b · Schempp C.M.a
aCompetence Center Skintegral and bAllergy Research Group, Department of Dermatology, University Medical Center Freiburg, Freiburg, cCassella-med GmbH & Co. KG, Cologne, and dInstitute of Medical Biometry and Clinical Epidemiology, Charité, Berlin, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 1/24/2008
Accepted: 5/9/2008
Published online: 7/31/2008
Issue release date: October 2008

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 2

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP

Abstract

Background: Dry and atopic skin requires skin care with lipid-rich emollients and moisturizing bath or shower oils. However, it has been shown recently that some bath oils may even impair the skin barrier. Objective: To investigate the skin-irritating potential of a new bath oil containing a lipophilic St. John’s wort (Hypericum perforatum) extract. Methods: In this single-center, randomized, double-blind, prospective study, 3 bath oils together with positive and negative controls were applied under occlusion on test areas on the volar forearms of 18 volunteers (visit 1). After 24 h, the tapes were removed, and the test areas were evaluated by a visual score and the instrumental measurement of skin erythema and transepidermal water loss (TEWL) using a Mexameter and a Tewameter (visit 2). The test substances were applied a second time, and the measurements were performed after another 24 h (visit 3). Results: The positive control, 1% vol/vol sodium lauryl sulfate (SLS), caused a significant increase in skin erythema and TEWL. In contrast, distilled water as a negative control did not influence these parameters. The new bath oil containing St. John’s wort extract and 1 of the other 2 commercial products were not different from the water control. The third bath oil displayed a skin-irritating effect similar to SLS. Conclusion: The results of this study confirm the different skin-irritating potential of bath oils and demonstrate good skin tolerance of the new bath oil containing St. John‘s wort extract.

© 2008 S. Karger AG, Basel


  

Author Contacts

C.M. Schempp
Competence Center Skintegral, Department of Dermatology
University of Freiburg, Hauptstrasse 7, DE–79104 Freiburg im Breisgau (Germany)
Tel. +49 76 1270 6701, Fax +49 76 1270 6829
E-Mail christoph.schempp@uniklinik-freiburg.de

  

Article Information

C.M.S. has received royalties from Cassella-med.

Received: January 24, 2008
Accepted after revision: May 9, 2008
Published online: July 31, 2008
Number of Print Pages : 6
Number of Figures : 3, Number of Tables : 2, Number of References : 28

  

Publication Details

Skin Pharmacology and Physiology (Journal of Pharmacological and Biophysical Research)

Vol. 21, No. 6, Year 2008 (Cover Date: October 2008)

Journal Editor: Lademann J. (Berlin)
ISSN: 1660–5527 (Print), eISSN: 1660–5535 (Online)

For additional information: http://www.karger.com/SPP


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 1/24/2008
Accepted: 5/9/2008
Published online: 7/31/2008
Issue release date: October 2008

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 2

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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