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Table of Contents
Vol. 82, No. 3, 2008
Issue release date: October 2008
Section title: Review
Free Access
Pharmacology 2008;82:171–179

The Contributions of Paul Ehrlich to Pharmacology: A Tribute on the Occasion of the Centenary of His Nobel Prize

Bosch F.a, b · Rosich L.a
aEsteve Foundation, and bDepartment of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain
email Corresponding Author

Fèlix Bosch

Esteve Foundation

Llobet i Vall-Llosera, 2

ES–08032 Barcelona (Spain)

Tel. +34 934 335 320, Fax +34 934 504 899, E-Mail fbosch@esteve.org

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On the centenary of Paul Ehrlich’s Nobel Prize, this German researcher deserves to be remembered as a pioneer in a large number of scientific disciplines. As a result of his enthusiasm and scientific abilities, dedication, and contacts with other scientists of his time, he was able to make countless contributions in fields as diverse as histology, haematology, immunology, oncology, microbiology and pharmacology, among others. Although the Swedish award was meant to recognize the standardization of the manufacture of antidiphtheria serum, it was the discovery of arsphenamine (Salvarsan) for the treatment of syphilis which won him wider international acclaim. From a pharmacological perspective, Ehrlich’s outstanding contributions include dissemination of the ‘magic bullet’ concept for the synthesis of antibacterials, introduction of concepts such as chemoreceptor and chemotherapy, and linking the chemical structure of compounds to their pharmacological activity. These achievements took place within the framework he established for the transition from experimental pharmacology to therapeutic pharmacology. He introduced a modern research system based on the synthesis of multiple chemical structures for pharmacological screening in animal models of disease states. These contributions were undoubtedly decisive in propitiating the wider development of antibiotics decades later. For these reasons, it is fitting to mark the 100th anniversary of the Nobel Prize awarded to this great scientist by commemorating the importance of his contributions to the advance of pharmacology.

© 2008 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Review

Received: February 29, 2008
Accepted: May 16, 2008
Published online: August 05, 2008
Issue release date: October 2008

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 1

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: http://www.karger.com/PHA

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