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Table of Contents
Vol. 31, No. 4, 2008
Issue release date: September 2008
Section title: Original Paper
Kidney Blood Press Res 2008;31:268–273
(DOI:10.1159/000151286)

Lack of Association of Functional Variants in Alpha-ENaC Gene and Essential Hypertension in Two Ethnic Groups in China

Wang X.a · Lu X.b · Lin R.b · Wang S.b · Zhang L.c · Qian J.a · Lu D.a · Wen H.b · Jin L.a
aMOE Key Laboratory of Contemporary Anthropology and Center for Evolutionary Biology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, and bFirst Affiliated Hospital, cCollege of Medicine, Xinjiang Medical University, Urumqi, China

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: November 05, 2007
Accepted: June 24, 2008
Published online: August 15, 2008
Issue release date: September 2008

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 3

ISSN: 1420-4096 (Print)
eISSN: 1423-0143 (Online)

For additional information: http://www.karger.com/KBR

Abstract

Background: It has been proposed that subtle genetic changes in epithelial sodium channel (ENaC) subunits might be at the origin of less rare forms of hypertension. In some populations, subtle functional genetic changes in ENaC genes associated with essential hypertension were indeed observed. To further test this hypothesis, we observed the role of three functional variants G2139A, A334T and A663T in the alpha-ENaC gene on essential hypertension in two Chinese minority groups, the Kazaks and Uyghurs. Methods: A population-based case-control study was carried out in the two populations mentioned above. Results: The distribution of genotype and allele frequencies of G2139A, A334T and A663T did not differ significantly between hypertensive subjects and control subjects in both Kazak and Uyghur populations. No significant associations of the three polymorphisms with hypertension were observed in both populations in univariate and multivariate logistic regression analysis by applying dominant, additive and recessive models. Haplotype-based association analysis based on G2139A, A334T and A663T did not show significant association between hypertensive subjects and control subjects in both populations. Conclusions: For the above variants, we did not confirm the hypothesis that subtle genetic changes in alpha-ENaC subunits might be at the origin of essential hypertension in our populations.

© 2008 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: November 05, 2007
Accepted: June 24, 2008
Published online: August 15, 2008
Issue release date: September 2008

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 3

ISSN: 1420-4096 (Print)
eISSN: 1423-0143 (Online)

For additional information: http://www.karger.com/KBR


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