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The gene encoding the transcriptional repressor BERF-1 maps to a region of conserved synteny on mouse chromosome 16 and human chromosome 3 and a related pseudogene maps to mouse chromosome 8

Antona V.a · Cammarata G.c · De Gregorio L.d · Dragani T.A.d · Giallongo A.c · Feo S.a,b

Author affiliations

aDipartimento di Biologia Cellulare e dello Sviluppo, Università di Palermo; bCentro di Oncobiologia Sperimentale; cIstituto di Biologia dello Sviluppo del Consiglio Nazionale delle Ricerche, Palermo; and dDivisione di Oncologia Sperimentale A, Istituto Nazionale Tumori, Milano (Italy)

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Cytogenet Cell Genet 83:90–92 (1998)

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: February 01, 1999
Issue release date: 1998

Number of Print Pages: 3
Number of Figures: 3
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR

Abstract

Abstract.

We have recently identified and characterized a Kruppel-like zinc finger protein (BERF-1), that functions as a repressor of β enolase gene transcription. By interspecific backcross analysis the gene encoding BERF-1 was localized 4.7 cM proximal to the Mtv6 locus on mouse chromosome 16, and an isolated pseudogene was localized to mouse chromosome 8, about 5.3 cM distal to the D8Mit4 marker. Nucleotide sequence identity and chomosome location indicate that the gene encoding BERF-1 is the mouse homologue (Zfp148) of ZNF148 localized to human chromosome 3q21, a common translocation site in acute myeloid leukemia patients.


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: February 01, 1999
Issue release date: 1998

Number of Print Pages: 3
Number of Figures: 3
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


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