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Vol. 81, No. 3, 2008
Issue release date: October 2008
Section title: Original Paper
Urol Int 2008;81:306–311
(DOI:10.1159/000151409)

Identification of Immunohistochemical Factors That Predict the Synchronous or Metachronous Development of Bladder Tumors in Patients with Upper Urinary Tract Tumors

Joung J.Y. · Yang S.O. · Jeong I.G. · Han K.S. · Seo H.K. · Chung J. · Park W.S. · Lee G.K. · Lee K.H.
aUrologic Oncology Clinic and bDepartment of Pathology, Institute and Hospital, National Cancer Center, Goyang, Korea

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/22/2007
Accepted: 8/21/2007
Published online: 10/16/2008

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 5

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN

Abstract

Objective: To identify markers that predict the synchronous or metachronous development of bladder cancer in patients with upper urinary tract (UUT) tumors. Materials and Methods: Between March 2001 and December 2005, we identified 38 consecutive patients who had been histologically diagnosed as having transitional cell carcinoma in the renal pelvis and ureter. These patients were divided into 2 groups (n = 19 per group): group 1 patients with metachronous or synchronous bladder cancer, and group 2 patients with UUT tumors only. We analyzed the differences between the 2 groups with respect to the expression of various biomarkers (p53, Rb, Ki-67, PTEN, and bcl-2) and in terms of clinical parameters. Results: The 2 groups differed significantly in terms of multiplicity (p = 0.029), papillary configuration (p = 0.001), the presence of lymphovascular emboli (p = 0.019), and Ki-67 overexpression (p = 0.029) in UUT tumors. Multivariate analysis revealed that Ki-67 overexpression in UUT tumor tissues significantly predicts bladder cancer development (HR 6.440; 95% CI 1.121–37.014; log rank p = 0.037). Conclusion: Ki-67 overexpression in UUT tumor tissues was found to be an independent predictor of the development of bladder cancer in UUT tumor patients.


  

Author Contacts

Kang Hyun Lee, MD, PhD
Urologic Oncology Clinic, Institute and Hospital
National Cancer Center, 809 Madu-Dong, Ilnsan-Gu
Goyang, Gyonggi 411-769 (Korea)
Tel. +82 31 920 1676, Fax +82 31 920 1520, E-Mail uroonco@ncc.re.kr

  

Article Information

Received: March 22, 2007
Accepted after revision: August 21, 2007
Published online: October 16, 2008
Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 5, Number of References : 19

  

Publication Details

Urologia Internationalis

Vol. 81, No. 3, Year 2008 (Cover Date: October 2008)

Journal Editor: Wirth M.P. (Dresden), Porena M. (Perugia), Hakenberg O.W. (Rostock), Castro-Diaz D. (Santa Cruz de Tenerife)
ISSN: 0042–1138 (Print), eISSN: 1423–0399 (Online)

For additional information: http://www.karger.com/UIN


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/22/2007
Accepted: 8/21/2007
Published online: 10/16/2008

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 5

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN


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