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Vol. 83, No. 3-4, 1998
Issue release date: 1998
Section title: Paper
Cytogenet Cell Genet 83:232–235 (1998)
(DOI:10.1159/000015188)

Cloning of a novel gene (ING1L) homologous to ING1, a candidate tumor suppressor

Shimada Y. · Saito A. · Suzuki M. · Takahashi E. · Horie M.
Otsuka GEN Research Institute, Otsuka Pharmaceutical Co., Ltd., Tokushima (Japan)

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 3/3/1999
Issue release date: 1998

Number of Print Pages: 4
Number of Figures: 5
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR

Abstract

Abstract.

The ING1 gene encodes p33ING1, a putative tumor suppressor for neuroblastomas and breast cancers, which has been shown to cooperate with p53 in controlling cell proliferation. We have isolated a novel human gene, ING1L, that potentially encodes a PHD-type zinc-finger protein highly homologous to p33ING1. Fluorescence in situ hybridization and radiation-hybrid analyses assigned ING1L to human chromosome 4. Both ING1 and ING1L are expressed in a variety of human tissues, but we found ING1L expression to be significantly more pronounced in tumors from several colon-cancer patients than in normal colon tissues excised at the same surgical sites. Although the significance of this observation with respect to carcinogenesis remains to be established, the data suggest that ING1L might be involved in colon cancers through interference with signal(s) transmitted through p53 and p33ING1.


  

Author Contacts

Request reprints from Dr. Masato Horie, Otsuka GEN Research Institute,Otsuka Pharmaceutical Co., Ltd., 463-10 Kagasuno, Kawauchi-cho,Tokushima 771-0192 (Japan); telephone: 81-886-65-2888;fax: 81-886-37-1035; email: mhorie@otsuka.genome.ad.jp

  

Article Information

Supported in part by a Grant-in-Aid for Scientific Research on Priority Areas from the Ministry of Education, Science, Sports, and Culture, Japan (E.T.).

Received: Received 8 June 1998;
revision accepted 19 October 1998.
Number of Print Pages : 4
Number of Figures : 5, Number of Tables : 0, Number of References : 14

  

Publication Details

Cytogenetics and Cell Genetics
Founded 1962 as Cytogenetics by H.P. Klinger

Vol. 83, No. 3-4, Year 1998 (Cover Date: 1998)

Journal Editor: H.P. Klinger, New York, USA
ISSN: 0301–0171 (print), 1422–9816 (Online)

For additional information: http://www.karger.com/journals/ccg


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 3/3/1999
Issue release date: 1998

Number of Print Pages: 4
Number of Figures: 5
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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