Journal Mobile Options
Table of Contents
Vol. 84, No. 3-4, 1999
Issue release date: 1999
Section title: Paper
Cytogenet Cell Genet 84:173–178 (1999)
(DOI:10.1159/000015249)

Characterization of the human laminin β2 chain locus (LAMB2): linkage to a gene containing a nonprocessed, transcribed LAMB2-like pseudogene (LAMB2L) and to the gene encoding glutaminyl tRNA synthetase (QARS)

Durkin M.E. · Jäger A.C. · Khurana T.S. · Nielsen F.C. · Albrechtsen R. · Wewer U.M.
aInstitute of Molecular Pathology, University of Copenhagen, Copenhagen; bDepartment of Clinical Biochemistry, Rigshospitalet, Copenhagen; cDepartment of Clinical Biochemistry, Glostrup Hospital, Glostrup (Denmark)

Do you have an account?

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger (new!)
  • Unrestricted printing, no saving restrictions for personal use
  • Reduced rates with a PPV account
read more

Direct: USD 38.00
Account: USD 26.50

Select

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Automatic perpetual access to all articles of the subscribed year(s)
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 6/14/1999

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR

Abstract

Abstract.

The laminin β2 chain is an important constituent of certain kidney and muscle basement membranes. We have generated a detailed physical map of a 110-kb genomic DNA segment surrounding the human laminin β2 chain gene (LAMB2) on chromosome 3p21.3→p21.2, a region paralogous with the chromosome 7q22→q31 region that contains the laminin β1 chain gene locus (LAMB1). Several CpG islands and a novel polymorphic microsatellite marker (D3S4594) were identified. The 3′ end of LAMB2 lies 16 kb from the 5′ end of the glutaminyl tRNA synthetase gene (QARS). About 20 kb upstream of LAMB2 we found a gene encoding a transcribed, non-processed LAMB2-like pseudogene (LAMB2L). The sequence of 1.75 kb of genomic DNA at the 3′ end of LAMB2L was similar to exons 8–12 of the laminin β2 chain gene. The LAMB2L–LAMB2–QARS cluster lies telomeric to the gene encoding the laminin-binding protein dystroglycan (DAG1).


  

Author Contacts

Request reprints from Dr. Ulla M. Wewer, Institute of Molecular Pathology, University of Copenhagen, Frederik V’s vej 11, DK–2100 Copenhagen (Denmark); telephone: 45 35 32 60 56; fax: 45 35 32 60 81; e-mail: molera@inet.uni-c.dk
M.E.D.’s present address is National Cancer Institute, Building 37 Room 3C28, 37 Convent Dr., Bethesda, MD 20892 (USA)

  

Article Information

Supported by grants from the Danish Cancer Society and the Danish Medical Research Council and by the VELUX, Novo-Nordisk, Haensch, Munksholm, Beckett, Hartmann, and Meyer Foundations.

Received: Received 23 November 1998;
revision accepted 2 March 1999.
Number of Print Pages : 6
Number of Figures : 2, Number of Tables : 2, Number of References : 32

  

Publication Details

Cytogenetics and Cell Genetics
Founded 1962 as Cytogenetics by H.P. Klinger

Vol. 84, No. 3-4, Year 1999 (Cover Date: 1999)

Journal Editor: H.P. Klinger, Bronx, N.Y.
ISSN: 0301–0171 (print), 1422–9816 (Online)

For additional information: http://www.karger.com/journals/ccg


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 6/14/1999

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.