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Table of Contents
Vol. 33, No. 6, 1983
Issue release date: 1983
Section title: Original Paper
Hum Hered 1983;33:377–389
(DOI:10.1159/000153406)

Evaluating Pedigree Data

II. Identifying the Cause of Error in Families with Inconsistencies

Lathrop G.M.a,c · Huntsman J.W.b · Hooper A.B.b · Ward R.H.c
aMusée de l’Homme, Place du Trocadero, Paris, France; bDepartment of Anthropology, University of Auckland, Auckland, New Zealand; cDepartment of Medical Genetics, University of British Columbia, Vancouver, B.C., Canada

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: September 02, 2008
Issue release date: 1983

Number of Print Pages: 13
Number of Figures: 0
Number of Tables: 0

ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)

For additional information: http://www.karger.com/HHE

Abstract

Pedigree data can be evaluated, and subsequently corrected, by analysis of the distribution of genetic markers, taking account of the possibility of mistyping. Using a model of pedigree error developed previously, we obtained the maximum likelihood estimates of error parameters in pedigree data from Tokelau. Posterior probabilities for the possible true relationships in each family are conditional on the putative relationships and the marker data are calculated using the parameter estimates. These probabilities are used as a basis for discriminating between pedigree error and genetic marker error in families where inconsistencies have been observed. When applied to the Tokelau data and compared with the results of retyping inconsistent families, these statistical procedures are able to discriminate between pedigree and marker error, with approximately 90% accuracy, for families with two or more offspring. The large proportion of inconsistencies inferred to be due to marker error (61 %) indicates the importance of discriminating between error sources when judging the reliability of putative relationship data. Application of our model of pedigree error has proved to be an efficient way of determining and subsequently correcting sources of error in extensive pedigree data collected in large surveys.

© 1983 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: September 02, 2008
Issue release date: 1983

Number of Print Pages: 13
Number of Figures: 0
Number of Tables: 0

ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)

For additional information: http://www.karger.com/HHE


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