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Table of Contents
Vol. 15, No. 3, 2008
Issue release date: October 2008
Section title: Special Topic Section: The Impact of Nutrition on Neuroimmunomodulation Editor: ...
Neuroimmunomodulation 2008;15:176–188
(DOI:10.1159/000153422)

Neonatal Programming of Neuroimmunomodulation – Role of Adipocytokines and Neuropeptides

de Moura E.G.a · Lisboa P.C.a · Passos M.C.F.b
aDepartamento de Ciências Fisiológicas, Instituto de Biologia Roberto Alcantara Gomes, and bDepartamento de Nutrição Aplicada, Instituto de Nutrição, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brasil

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Article / Publication Details

First-Page Preview
Abstract of Special Topic Section: The Impact of Nutrition on Neuroimmunomodulation Editor: ...

Published online: September 09, 2008
Issue release date: October 2008

Number of Print Pages: 13
Number of Figures: 2
Number of Tables: 0

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: http://www.karger.com/NIM

Abstract

Programming is an epigenetic phenomenon by which nutrition, environment and stress acting in a critical period earlier in life change the organism‘s development. This process was evolutionarily selected as an adaptive tool for the survival of organisms living in nutritionally deficient areas and submitted to stressful conditions. Thus, perinatal malnutrition turns on different genes that provide the organism with a thrifty phenotype. In conditions of abundant supply of nutrients, those programmed organisms can be at risk of developing metabolic diseases (obesity, dyslipidemia, diabetes and hypertension). How nutrition or neonatal stress can program the immune system is less well known. Here, we discuss some of the hormonal and metabolic changes that occur in mothers and neonates and how those factors can imprint hormonal or metabolic changes that program neuroimmunomodulatory effects. Some of these changes involve thyroid hormones, leptin, insulin, glucocorticoids and prolactin as potential imprinting factors. Most of them can be transferred through the milk and may change with malnutrition or stress. We discuss the programming effects of these hormones upon body weight, body composition, insulin action, thyroid, adrenal and immune and inflammatory responses, with special emphasis on leptin, a cytokine that seems to play a central role in these events.

© 2008 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Special Topic Section: The Impact of Nutrition on Neuroimmunomodulation Editor: ...

Published online: September 09, 2008
Issue release date: October 2008

Number of Print Pages: 13
Number of Figures: 2
Number of Tables: 0

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: http://www.karger.com/NIM


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.