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Vol. 15, No. 3, 2008
Issue release date: October 2008
Section title: Special Topic Section: The Impact of Nutrition on Neuroimmunomodulation Editor: ...
Neuroimmunomodulation 2008;15:189–193
(DOI:10.1159/000153423)

Diet-Induced Inflammation of the Hypothalamus in Obesity

Velloso L.A. · Araújo E.P. · de Souza C.T.
Department of Internal Medicine, State University of Campinas, Campinas, Brazil

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Article / Publication Details

First-Page Preview
Abstract of Special Topic Section: The Impact of Nutrition on Neuroimmunomodulation Editor: ...

Published online: 9/9/2008
Issue release date: October 2008

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 0

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: http://www.karger.com/NIM

Abstract

Dysfunction of specific hypothalamic neurons is regarded as an important mechanism predisposing to the development of obesity. Recent studies have revealed that the consumption of fat-rich foods can activate an inflammatory response in the hypothalamus, which disturbs the anorexigenic and thermogenic signals generated by the hormones leptin and insulin, leading in turn to anomalous body mass control. Depending on diet composition, cytokines are expressed in the hypothalamus, contributing to the activation of intracellular inflammatory signal transduction. At least 4 distinct signaling pathways have been identified and the molecular mechanisms leading to the impairment of the leptin and insulin actions have been determined. Here, we present the mechanisms involved in diet-induced resistance to leptin and insulin action in the hypothalamus and discuss some of the potential applications of this knowledge in the therapeutics of obesity.

© 2008 S. Karger AG, Basel


  

Author Contacts

Lício A. Velloso
Departamento de Clínica Médica
FCM – UNICAMP
13084-970 Campinas (Brazil)
E-Mail lavelloso@fcm.unicamp.br

  

Article Information

Published online: September 9, 2008
Number of Print Pages : 5
Number of Figures : 2, Number of Tables : 0, Number of References : 31

  

Publication Details

Neuroimmunomodulation

Vol. 15, No. 3, Year 2008 (Cover Date: October 2008)

Journal Editor: Savino W. (Rio de Janeiro)
ISSN: 1021–7401 (Print), eISSN: 1423–0216 (Online)

For additional information: http://www.karger.com/NIM


Article / Publication Details

First-Page Preview
Abstract of Special Topic Section: The Impact of Nutrition on Neuroimmunomodulation Editor: ...

Published online: 9/9/2008
Issue release date: October 2008

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 0

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: http://www.karger.com/NIM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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