Nonorgan-Specific Autoantibodies and Immunoglobulin Allotypes in Relatives of Patients with Monoclonal GammopathyYouinou P. · Fauchier C. · Prou O. · Rivat-Peran L. · Jouquan J. · Moysan J.F. · Le Menn G.
aClinique Médicale Harvier, Centre Hospitalier Universitaire, Brest, France; bLaboratoire d’Histo-compatibilité, Centre National de Transfusion Sanguine, Paris, France; cUnite 78 Inserm, Bois-Guillaume, France
Polyclonal immunoglobulin increase, rheumatoid factor, antinuclear antibodies and cold lymphocytotoxins were detected 10, 8, 7 and 8 times, respectively, in a group of these informative families (22, 17 and 29 subjects tested, respectively). Each family included at least 1 subject with a monoclonal gammopathy in addition to that of the proband. No correlation could be shown between any of these abnormalities and Gm haplotypes. Nonetheless, it is worth noting that 6 out of 41 relatives under 30 years of age had cold lymphocytotoxins.
Dr. P. Youinou, Laboratoire d’Immunologie, Centre Hospitalier Universitaire, F-29279 Brest Cédex (France)
Published online: September 02, 2008
Number of Print Pages : 5
Human Heredity (International Journal of Human and Medical Genetics)
Vol. 35, No. 4, Year 1985 (Cover Date: 1985)
Journal Editor: Devoto M. (Philadelphia, Pa.)
ISSN: 0001–5652 (Print), eISSN: 1423–0062 (Online)
For additional information: http://www.karger.com/HHE