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Vol. 40, No. 2, 1990
Issue release date: 1990
Section title: Original Paper
Hum Hered 1990;40:69–76
(DOI:10.1159/000153908)

A Genetic Study of Immunoglobulin E and Atopic Disease Based on Families Ascertained through Asthmatic Children

Parks T.a · Felix K.b · Rice T.a · Subbarao P.V.c · Marimuthu K.M.b · Rao D.C.a
aDivision of Biostatistics, Washington University School of Medicine, St. Louis, Mo., USA; bGenetics Department, P.G. Institute of Basic Medical Sciences, Taramani, Madras, India, and cAllergy and Applied Immunology Laboratory, Biochemistry Department, Indian Institute of Science, Bangalore, India

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 9/2/2008
Issue release date: 1990

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)

For additional information: http://www.karger.com/HHE

Abstract

In order to investigate the modes of inheritance of serum immunoglobulin E (IgE) levels and atopic disease, serum IgE levels and data on allergic disease were obtained from 42 families ascertained through asthmatic children visiting an allergy clinic. Although the mean IgE levels were elevated (mean 637 U/ml), the prevalence of atopic disease in this population was surprisingly low. When the data were analyzed using complex segregation analysis, no major locus could be detected. Moreover, the polygenic heritability was unexpectedly small even though the correlation between serum IgE levels and the liability to atopic disease was around 0.4. Given this unusual set of findings, it is postulated that parasitic infections in this population have (in accordance with well-established results of parasitic disease) caused both elevated levels of serum IgE and a decreased prevalence of allergic disease with the possible masking of the various genetic components of serum IgE levels and atopic disease.

© 1990 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 9/2/2008
Issue release date: 1990

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)

For additional information: http://www.karger.com/HHE


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