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Table of Contents
Vol. 42, No. 1, 1992
Issue release date: 1992
Section title: Models and Methods for the Genetic Analysis of Pedigree Data
Hum Hered 1992;42:9–15
(DOI:10.1159/000154042)

Genetics and Biology: A Comment on the Significance of the Elston-Stewart Algorithm

Stewart J.
Department of Immunobiology, Institut Pasteur, Paris, France

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Article / Publication Details

First-Page Preview
Abstract of Models and Methods for the Genetic Analysis of Pedigree Data

Published online: September 02, 2008
Issue release date: 1992

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)

For additional information: http://www.karger.com/HHE

Abstract

This article recounts the background to the development of the Elston-Stewart algorithm for the genetic analysis of pedigree data. The algorithm can be used in the context of two contrasting research programmes. The first approach is analytical and reductionist. Traditional biological disciplines, such as physiology, embryology and comparative biology, describe phenomenological domains in which biological organisms are treated as complex systems with emergent properties. In the reductionist approach, these biological domains are largely abandoned in favour of descriptions in the domain of the component elements of these systems, resulting in a concentration on molecular genetics as the central object of biological science. In the second approach, it is explicitly recognized that genes and molecules, per se, cannot be explanatory with respect to emergent systemic properties. However, since the genetic variation which occurs in natural populations can influence virtually every aspect and level of biological organization, from cell lineages to ecology, the study of such variation opens new possibilities for establishing meaningful articulations between the various biological disciplines. The author’s expressed preference is for the second alternative.

© 1992 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Models and Methods for the Genetic Analysis of Pedigree Data

Published online: September 02, 2008
Issue release date: 1992

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)

For additional information: http://www.karger.com/HHE


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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