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Vol. 42, No. 6, 1992
Issue release date: 1992
Section title: Original Paper
Hum Hered 1992;42:337–346
(DOI:10.1159/000154096)

A Haplotype-Based Haplotype Relative Risk’ Approach to Detecting Allelic Associations

Terwilliger J.D. · Ott J.
Department of Genetics and Development, Columbia University, New York, N.Y., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 9/2/2008
Issue release date: 1992

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0

ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)

For additional information: http://www.karger.com/HHE

Abstract

A novel variation of the Haplotype Relative Risk (HRR) of Rubinstein et al. [Hum Immunol 1981;3:384] is proposed, in order to glean increased information about linkage disequilibrium or allelic associations by analyzing haplotype-based data rather than genotypic data. It is shown that statistical tests based on our design give much higher power than those based on the original HRR approach. Several additional nonparametric tests based on the same data are analyzed, and power is computed for each of them. Further, parametric likelihood methods are applied to testing linkage equilibrium, and estimating δ, the coefficient of linkage disequilibrium, from the same data.

© 1992 S. Karger AG, Basel


  

Author Contacts

Joseph D. Terwilliger, 722 West 168th St. Box 58, New York, NY 10032 (USA)

  

Article Information

Published online: September 02, 2008
Number of Print Pages : 10

  

Publication Details

Human Heredity (International Journal of Human and Medical Genetics)

Vol. 42, No. 6, Year 1992 (Cover Date: 1992)

Journal Editor: Devoto M. (Philadelphia, Pa.)
ISSN: 0001–5652 (Print), eISSN: 1423–0062 (Online)

For additional information: http://www.karger.com/HHE


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 9/2/2008
Issue release date: 1992

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0

ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)

For additional information: http://www.karger.com/HHE


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