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Vol. 44, No. 6, 1994
Issue release date: 1994
Hum Hered 1994;44:337–343
(DOI:10.1159/000154241)
Original Paper

Estimating the Frequency of Nonpaternity in Switzerland

Sasse G.a · Müller H.a · Chakraborty R.b · Ott J.c
aRG Human Genetics, Department of Research, University Clinics, Kantonsspital, University of Basel, Switzerland; bCenter for Demographic and Population Genetics, University of Texas, Houston, Tex., and Department of Genetics and Development and cDepartment of Psychiatry, Columbia University, New York, N.Y., USA

Abstract

In linkage analysis and gene mapping in general, typing error and/or errors in specifying pedigree relationships between individuals typically lead to an upwards bias in recombination fraction estimates and to a loss of power for detecting linkage. [Ott J: Analysis of Human Genetic Linkage. Baltimore, Johns Hopkins University Press, 1991]. The presence of nonpaternity is the most common source of error of misspecification of pedigree relationships between individuals that can have a negative impact on pedigree analysis. We have developed estimates of underlying nonpaternity probabilities based on observed Mendelian inconsistencies. The methods were applied to a sample of 1,607 children and their parents. Genetic marker data were investigated to test for exclusions due to nonpaternity. Among the 1,607 children, 11 or 0.68% exclusions were found. When a constant nonpaternity rate was assumed for each child, its maximum likelihood estimate turned out to be 0.78% with asymptotic 95% confidence limits of 0.41% and 1.35%. When varying nonpaternity rates were assumed, its mean was estimated as 0.83% with asymptotic 95% confidence limits of 0.32% and 1.33%.

 goto top of outline Author Contacts

Dr. Jürg Ott, Psychiatric Institute, Unit 58, 722 West 168 Street, New York, NY 10032 (USA)


 goto top of outline Article Information

Received: March 28, 1994
Accepted: May 25, 1994
Published online: September 03, 2008
Number of Print Pages : 7


 goto top of outline Publication Details

Human Heredity (International Journal of Human and Medical Genetics)

Vol. 44, No. 6, Year 1994 (Cover Date: 1994)

Journal Editor: Devoto M. (Philadelphia, Pa.)
ISSN: 0001–5652 (Print), eISSN: 1423–0062 (Online)

For additional information: http://www.karger.com/HHE


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