Yacon is a root crop which contains high amounts of fructooligosaccharides (FOS). The aim of this study was to investigate the effects of yacon syrup on colon transit time in healthy volunteers. Methods:
In a placebo-controlled, double-blind study yacon was administered to 16 healthy individuals (8 males, 8 females) in a dose of 20 g daily (equal to 6.4 g FOS) in a 2-week crossover design. Each period was interrupted by a 2-week wash-out phase. Transit time was assessed by a radio-opaque marker technique. Results:
Transit time (mean ± SEM) through the gastrointestinal tract was significantly decreased from 59.7 ± 4.3 to 38.4 ± 4.2 h (p < 0.001). Yacon was well tolerated with an excellent side effect profile. Bloating is not an uncommon side effect observed with FOS, but bloating-related disturbances were not significantly more often reported with yacon compared to placebo. Stool frequency increased from 1.1 ± 0.1 to 1.3 ± 0.2 times per day and the consistency showed a tendency for softer stools as assessed by a numerical depicted stool protocol. Neither parameter did, however, reach statistical significance. Conclusion:
Yacon markedly accelerates colonic transit in healthy individuals. Further studies are needed in constipated patients to confirm these preliminary data. Due to the low caloric content of yacon, the root could be a useful treatment in constipated diabetics or obese patients.
- Seminario J, Valderrama M, Manrique I: El yacón: fundamentos para el aprovechamiento de un recurso promisorio. Centro Internacional de la Papa (CIP), Universidad Nacional de Cajamarca, Agencia Suiza para el Desarrollo y la Cooperación (COSUDE), Lima, 2003, p 60.
- Genta SB, Cabera WM, Grau A, Sánchez SS: Subchronic 4-month oral toxicity study of dried Smallanthus sonchifolius (yacon) roots as a diet supplement in rats. Food Chem Toxicol 2005;43:1657–1665.
- Coussement PA: Inulin and oligofructose: safe intakes and legal status. J Nutr 1999;129(suppl 7):1412S–1417S.
- Silva RF: Use of inulin as a natural texture modifier. Cereal Food World 1996;41:792–794.
- Hirayama M: Novel physiological functions of oligosaccharides. Pure Appl Chem 2002;74:1271–1279.
- Chen HL, Lu YH, Lin J, Ko LY: Effects of fructooligosaccharide on bowel function and indicators of nutritional status in constipated elderly men. Nutr Res 2000;20:1725–1733.
- Manrique I, Párraga A, Hermann M: Yacon syrup: principles and processing; in Conservación y uso de la biodiversidad de raíces y tubérculos andinos: una década de investigación para el desarrollo (1993–2003). No. 8B. International Potato Center, Universidad Nacional Daniel Alcides Carrión, Erbacher Foundation, Swiss Agency for Development and Cooperation, Lima, 2005, p 31.
- Luo J, Van Yperselle M, Rizkalla S, Rossi F, Bornet F, Slama G: Chronic consumption of short-chain fructooligosaccharides does not affect basal hepatic glucose productin or insulin resistance in type 2 diabetics. J Nutr 2000;130:1572–1577.
- Meier R, Beglinger C, Dederding JP, Meyer-Wyss B, Fumagalli M, Rowedder A, Turberg Y, Brignoli R: Influence of age, gender, hormonal status and smoking habits on colonic transit time. Neurogastroenterol Motil 1995;7:235–238.
- O’Donnell LJ, Virjee J, Heaton KW: Detection of pseudodiarrhoea by simple clinical assessment of intestinal transit rate. BMJ 1990;300:439–440.
- Mitsuoka T, Hidaka H, Eida T: Effect of fructo-oligosaccharides on intestinal microflora. Nahrung 1987;31:427–436.
- Cummings JH, Macfarlane GT, Englyst HN: Prebiotic digestion and fermentation. Am J Clin Nutr 2000;73(suppl):415S–420S.
- Scholz-Ahrens KE, Acil Y, Schrezenmeir J: Effect of oligofructose or dietary calcium on repeated calcium and phosphorus balances, bone mineralization and trabecular structure in ovariectomized rats. Br J Nutr 2002;88:365–377.
- Scholz-Ahrens KE, Schrezenmeir J:Inulin, oligofructose and mineral metabolism – experimental data and mechanism. Br J Nutr 2002;87(suppl 2):S179–S186.
- Kruger MC, Brown KE, Collett G, Layton L, Schollum LM: The effect of fructooligosaccharides with various degrees of polymerisation on calcium bioavailability in the growing rat. Exp Biol Med2003;228:683–688.
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Received: November 26, 2007
Accepted: July 23, 2008
Published online: September 10, 2008
Number of Print Pages : 4
Number of Figures : 2, Number of Tables : 2, Number of References : 16
Digestion (International Journal of Gastroenterology)
Vol. 78, No. 1, Year 2008 (Cover Date: November 2008)
Journal Editor: Beglinger C. (Basel), Göke B. (Munich)
ISSN: 0012–2823 (Print), eISSN: 1421–9867 (Online)
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