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Vol. 89, No. 1-2, 2000
Issue release date: 2000
Section title: Paper
Cytogenet Cell Genet 89:67–78 (2000)
(DOI:10.1159/000015567)

Conserved synteny between the chicken Z sex chromosome and human chromosome 9 includes the male regulatory gene DMRT1: a comparative (re)view on avian sex determination

Nanda I. · Zend-Ajusch E. · Shan Z. · Grützner F. · Schartl M. · Burt D.W. · Koehler M. · Fowler V.M. · Goodwin G. · Schneider W.J. · Mizuno S. · Dechant G. · Haaf T. · Schmid M.
aDepartment of Human Genetics, Biocenter, University of Würzburg, Würzburg (Germany); bMax-Planck-Institute of Molecular Genetics, Berlin (Germany); cDepartment of Physiological Chemistry I, Biocenter, University of Würzburg, Würzburg (Germany); dRoslin Institute (Edinburgh), Roslin, Midlothian, Scotland (UK); eDepartment of Cell Biology, Scripps Research Institute, La Jolla, CA (USA); fInstitute of Cancer Research, Haddow Laboratories, Surrey (UK); gDepartment of Molecular Genetics, Biocenter, University of Vienna, Vienna (Austria); hDepartment of Applied Biological Chemistry, Tohoku University, Sendai (Japan); and iMax-Planck-Institute for Psychiatry, Martinsried (Germany)

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 6/26/2000
Issue release date: 2000

Number of Print Pages: 12
Number of Figures: 7
Number of Tables: 2

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR

Abstract

Abstract.

Sex-determination mechanisms in birds and mammals evolved independently for more than 300 million years. Unlike mammals, sex determination in birds operates through a ZZ/ZW sex chromosome system, in which the female is the heterogametic sex. However, the molecular mechanism remains to be elucidated. Comparative gene mapping revealed that several genes on human chromosome 9 (HSA 9) have homologs on the chicken Z chromosome (GGA Z), indicating the common ancestry of large parts of GGA Z and HSA 9. Based on chromosome homology maps, we isolated a Z-linked chicken ortholog of DMRT1, which has been implicated in XY sex reversal in humans. Its location on the avian Z and within the sex-reversal region on HSA 9p suggests that DMRT1 represents an ancestral dosage-sensitive gene for vertebrate sex-determination. Z dosage may be crucial for male sexual differentiation/determination in birds.   


  

Author Contacts

Request reprints from Dr. Michael Schmid, Department of Human Genetics,University of Würzburg, Biozentrum, Am Hubland,D–97074 Würzburg (Germany); telephone: +49-931-888-4077;fax: +49-931-888-4069; e-mail: m.schmid@biozentrum.uni-wuerzburg.de

  

Article Information

Supported by research grants from the Commission of the European Communities (PL970 288) and the German Research Foundation (Ha 1374/5-1). Dedicated to Dr. Jennifer A. Marshall Graves in recognition of her outstanding contributions on vertebrate sex chromosomes.

Received: Received 19 January 2000;
revision accepted 28 February 2000.
Number of Print Pages : 12
Number of Figures : 7, Number of Tables : 2, Number of References : 65

  

Publication Details

Cytogenetics and Cell Genetics
Founded 1962 as Cytogenetics by H.P. Klinger

Vol. 89, No. 1-2, Year 2000 (Cover Date: 2000)

Journal Editor: H.P. Klinger, Bronx, N.Y.; M. Schmid, Würzburg
ISSN: 0301–0171 (print), 1422–9816 (Online)

For additional information: http://www.karger.com/journals/ccg


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 6/26/2000
Issue release date: 2000

Number of Print Pages: 12
Number of Figures: 7
Number of Tables: 2

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


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