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Vol. 89, No. 1-2, 2000
Issue release date: 2000
Section title: Paper
Cytogenet Cell Genet 89:89–91 (2000)
(DOI:10.1159/000015570)

Molecular cloning and characterization of a mouse homolog of human TNFSF14, a member of the TNF superfamily

Misawa K.a · Nosaka T.a · Kojima T.a · Hirai M.b · Kitamura T.a
aDepartment of Hematopoietic Factors, The Institute of Medical Science; and bDepartment of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo (Japan)

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 6/26/2000
Issue release date: 2000

Number of Print Pages: 3
Number of Figures: 4
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR

Abstract

Abstract.

A member of the tumor necrosis factor (TNF) superfamily, human TNFSF14 (hTNFSF14)/HVEM-L (herpes virus entry mediator ligand) was isolated as a cellular ligand for HVEM/TR2 and human lymphotoxin β receptor (LTβR). TNFSF14 induces apoptosis and suppresses tumor formation. We have isolated a cDNA clone for a mouse homologue of hTNFSF14 by signal sequence trap (SST) screening which we recently developed. The deduced amino acid sequence of the mouse TNFSF14 (mTNFSF14) cDNA comprised 239 amino acid residues and was 77% identical to the hTNFSF14 protein. In Northern blot analysis, 2.1 kb and 4.2kb mTNFSF14 transcripts were detected in spleen and lung, and in heart, respectively. Fluorescence in situ hybridization analysis localized the mTNFSF14 gene Tnfsf14 to chromosome 17 which is tightly linked with Tnf, Lta, and Ltb.   

© 2000 S. Karger AG, Basel


  

Author Contacts

Request reprints from Dr. Toshio Kitamura, Department of Hematopoietic Factors,The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai,Minato-ku, Tokyo 108-8639 (Japan); telephone: 81-3-5449-5758;fax: 81-3-5449-5453; e-mail: kitamura@ims.u-tokyo.ac.jp

  

Article Information

Supported in part by a grant-in-aid from the Ministry of Education, Science, Sports and Culture of Japan. The Department of Hematopoietic Factors is supported by Chugai Pharmaceutical Company Ltd.

Received: Received 1 December 1999;
revision accepted 25 February 2000.
Number of Print Pages : 3
Number of Figures : 4, Number of Tables : 0, Number of References : 14

  

Publication Details

Cytogenetics and Cell Genetics
Founded 1962 as Cytogenetics by H.P. Klinger

Vol. 89, No. 1-2, Year 2000 (Cover Date: 2000)

Journal Editor: H.P. Klinger, Bronx, N.Y.; M. Schmid, Würzburg
ISSN: 0301–0171 (print), 1422–9816 (Online)

For additional information: http://www.karger.com/journals/ccg


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 6/26/2000
Issue release date: 2000

Number of Print Pages: 3
Number of Figures: 4
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


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