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Vol. 89, No. 1-2, 2000
Issue release date: 2000
Section title: Paper
Cytogenet Cell Genet 89:101–106 (2000)
(DOI:10.1159/000015574)

Comparison of genomic structures of four members of β-galactoside α2,3-sialyltransferase genes in the mouse

Takashima S. · Tsuji S.
Molecular Glycobiology, Frontier Research Program, The Institute of Physical and Chemical Research (RIKEN), Wako, Saitama (Japan)

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 6/26/2000
Issue release date: 2000

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 4

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR

Abstract

Abstract.

The mouse genes encoding β-galactoside α2,3-sialyltransferases—Siat4 (ST3Gal I), Siat5 (ST3Gal II), Siat3 (ST3Gal III), and Siat4c (ST3Gal IV)—were isolated and characterized. Siat4 and Siat5 comprise 8.4 and 14 kb, respectively, and are composed of six exons each. The genomic structures of the two genes were similar. Siat3 and Siat4c comprise over 100 and 9.7 kb, respectively, and are composed of 12 and 10 exons, respectively. Although the genomic sizes of these genes differ, some of their exon structures are significantly similar. These results suggest that the gene pair Siat4 and Siat5 arose from a common ancestral gene, as did the two genes Siat3 and Siat4c.    

© 2000 S. Karger AG, Basel


  

Author Contacts

Request reprints from Dr. Shuichi Tsuji, Molecular Glycobiology, Frontier Research Program, The Institute of Physical and Chemical Research (RIKEN), Wako, Saitama 351-0198 (Japan); telephone: +81-463-85-5301; fax: +81-463-85-5301, e-mail: stsuji02@yhb.att.ne.jp.

  

Article Information

Supported by the Ministry of Education of Japan (Grants-in-Aid Nos. 10152263, 10178104, and 10178105 for Scientific Research on Priority Areas and Grant-in-Aid No. B11480184 for Scientific Research). The nucleotide sequences reported in this paper have been submitted to the GenBank/EBI Data Bank under accession numbers X73523 (Siat4 [mouse ST3Gal I]), X76989 (Siat5 [mouse ST3Gal II]), X84234 (Siat3 [mouse ST3Gal III]), and X95809 (Siat4c [mouse ST3Gal IV]). The nomenclature for gangliosides follows the system of Svennerholm (1964). The abbreviated nomenclature for cloned sialyltransferases follows the system of Tsuji et al. (1996): Gal = galactose; GalNAc = N-acetylgalactosamine; Sia = sialic acid. Shou Takashima’s present address is Neural Regeneration, Brain Science Institute, The Institute of Physical and Chemical Research (RIKEN), Wako, Saitama 351-0198 (Japan).

Received: Received 18 November 1999;
revision accepted 20 March 2000.
Number of Print Pages : 6
Number of Figures : 2, Number of Tables : 4, Number of References : 32

  

Publication Details

Cytogenetics and Cell Genetics
Founded 1962 as Cytogenetics by H.P. Klinger

Vol. 89, No. 1-2, Year 2000 (Cover Date: 2000)

Journal Editor: H.P. Klinger, Bronx, N.Y.; M. Schmid, Würzburg
ISSN: 0301–0171 (print), 1422–9816 (Online)

For additional information: http://www.karger.com/journals/ccg


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 6/26/2000
Issue release date: 2000

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 4

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


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