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Vol. 148, No. 2, 2009
Issue release date: January 2009
Section title: Original Paper
Int Arch Allergy Immunol 2009;148:161–169
(DOI:10.1159/000155747)

Comparative Study of Cluster and Conventional Immunotherapy Schedules with Dermatophagoides pteronyssinus in the Treatment of Persistent Allergic Rhinitis

Zhang L. · Wang C. · Han D. · Wang X. · Zhao Y. · Liu J.
aDepartment of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Key Laboratory of Otolaryngology Head and Neck Surgery, Capital Medical University, Ministry of Education, Beijing, and bSchool of Management, Tianjin University, Tianjin, PR China

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/22/2007
Accepted: 4/23/2008
Published online: 9/19/2008

Number of Print Pages: 9
Number of Figures: 5
Number of Tables: 4

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Background and Objectives: Allergy to house dust mite is one of the most common causes of allergic rhinitis (AR) in China. We sought to compare the efficacy and safety of a 6-week cluster schedule of specific immunotherapy with that of a 14-week conventional schedule for the treatment of subjects with persistent AR. Methods: The trial was a prospective and randomized study involving 96 patients with persistent AR, aged 14–60 years, who were allergic to Dermatophagoides pteronyssinus. While 48 patients were randomly assigned to the cluster schedule reaching the maintenance dose within 6 weeks, the other 48 were randomly assigned to the conventional schedule reaching the maintenance dose within 14 weeks. Eighty-nine patients completed a 1-year treatment course. While kinetic changes in clinical efficacy and adverse reactions were observed during the treatment, quality of life, cutaneous reactivity and serum-specific immunoglobulin E to Dermatophagoides pteronyssinus were measured before and after treatment. Results: The cluster schedule reduced the time to reach the maintenance dose by 57% and caused mild systemic adverse reactions after 1.0% of injections (6.7% of patients), with no differences in comparison with the conventional schedule. Cluster specific immunotherapy led to decreases in clinical symptoms and earlier use of medication than did the conventional schedule. Similar improvements in quality of life and reduced cutaneous reactivity without significant changes in specific immunoglobulin E were observed in both groups after 1 year. Conclusions: The cluster schedule is a safe alternative to the conventional schedule with the advantage of achieving clinical effectiveness sooner.


  

Author Contacts

Correspondence to: Dr. Demin Han
Beijing Institute of Otolaryngology
17, Hou Gou Hu Tong, Dong Cheng District
Beijing 100005 (PR China)
Tel. +86 10 6514 1136, Fax +86 10 8511 5988, E-Mail Luozhang@trhos.com

  

Article Information

Received: October 22, 2007
Accepted after revision: April 23, 2008
Published online: September 19, 2008
Number of Print Pages : 9
Number of Figures : 5, Number of Tables : 4, Number of References : 32

  

Publication Details

International Archives of Allergy and Immunology

Vol. 148, No. 2, Year 2009 (Cover Date: January 2009)

Journal Editor: Valenta R. (Vienna)
ISSN: 1018–2438 (Print), eISSN: 1423–0097 (Online)

For additional information: http://www.karger.com/IAA


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/22/2007
Accepted: 4/23/2008
Published online: 9/19/2008

Number of Print Pages: 9
Number of Figures: 5
Number of Tables: 4

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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